Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Steve Clark | GK |  | Portland Timbers | Portland |
| 12/2021 | | Daniel Steres | DF |  | Los Angeles Galaxy | L.A. Galaxy |
| 12/2021 |  | José Bizama | DF |  | Charlotte Independence | Charlotte Independence |
| 12/2021 | | Erik McCue | DF |  | Charleston Battery | Charleston Battery |
| 12/2021 | | Marcelo Palomino | MF | | Charlotte Independence | Charlotte Independence |
| 10/2021 |  | Juan Castilla | MF |  | Houston Dynamo U17 | U17 |
| 08/2021 |  | Adalberto Carrasquilla | MF |  | FC Cartagena | Cartagena |
| 07/2021 | | Corey Baird | FW |  | Los Angeles FC | Los Angeles |
| 07/2021 | | Griffin Dorsey | DF | |||
| 07/2021 |  | Teenage Hadebe | DF |  | Yeni Malatyaspor | Y. Malatyaspor |
| 01/2021 | | Kyle Morton | GK | |||
| 01/2021 | | Ethan Bartlow | DF |  | Washington Huskies | Washington Huskies |
| 01/2021 | | Derrick Jones | MF |  | Nashville SC | Nashville SC |
| 01/2021 |  | Mateo Bajamich | FW | |||
| 01/2021 | | Tim Parker | DF |  | New York RB | New York RB |
| 01/2021 | | Maxi Urruti | FW |  | CF Montréal | Montréal |
| 01/2021 |  | Tyler Pasher | FW |  | Indy Eleven | Indy Eleven |
| 01/2021 | | Joe Corona | MF |  | Austin FC | Austin FC |
| 01/2021 |  | Daniel Rios | MF |  | Rio Grande Valley FC | RGV FC |
| 01/2021 |  | Martín Vásquez | AS-CO | |||
| 01/2021 | | Joel Lockhart | AT-C | |||
| 01/2021 | | Steve Patera | AT-C |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 | | Kyle Morton | GK |  | Memphis 901 | Memphis 901 |
| 04/2021 |  | Ronaldo Peña | FW |  | Universidad Central | Universidad Central |
| 03/2021 |  | Niko Hansen | MF |  | Minnesota United FC | Minnesota Utd |
| 03/2021 | | Marcelo Palomino | MF | | Charlotte Independence | Charlotte Independence |
| 02/2021 | | Tyler Deric | GK | | Rio Grande Valley FC | RGV FC |
| 02/2021 | | Erik McCue | DF | | Charleston Battery | Charleston Battery |
| 02/2021 | | Víctor Cabrera | DF |  | Tigre | C. A. T. |
| 02/2021 | | Tomás Martínez | MF |  | Defensa y Justicia | CSyD DyJ |
| 01/2021 |  | Aljaž Struna | DF | | CF Montréal | Montréal |
| 01/2021 |  | Kyle Adams | DF |  | Real Monarchs SLC | Real Monarchs SLC |
| 01/2021 | | Cody Cropper | GK |  | FC Cincinnati | Cincinnati |
| 01/2021 | | Mauro Manotas | FW |  | Club Tijuana | Club Tijuana |
| 01/2021 | | Chris Rumsey | AT-C |  | Columbus Crew | Columbus Crew |