Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2022 |  | Andy Cabrera | MF |  | Butler Bulldogs | Butler Bulldogs |
| 12/2022 | | Zach Thornton | GK-CO |  | Houston Dynamo | H. Dynamo |
| 11/2022 |  | Andrés Calleja Blanco | AT-C | |||
| 05/2022 | | Mihajlo Mišković | GK | |||
| 05/2022 | | Chris Mueller | FW |  | Hibernian FC | Hibernian FC |
| 05/2022 |  | Ían Torres | MF |  | Atlas Guadalajara | Atlas |
| 02/2022 |  | Xherdan Shaqiri | MF |  | Olympique Lyonnais | Lyonnais |
| 01/2022 |  | Kacper Przybyłko | FW |  | Philadelphia Union 2 | Phil. Union 2 |
| 01/2022 | | Kendall Burks | DF |  | Washington Huskies | Washington Huskies |
| 01/2022 |  | Yanis Leerman | DF |  | Chicago Fire (Preseason) | Chicago Fire (Preseason) |
| 01/2022 | | Charlie Ostrem | DF | | Chicago Fire (Preseason) | Chicago Fire (Preseason) |
| 01/2022 | | Carlo Ritaccio | DF | | Chicago Fire (Preseason) | Chicago Fire (Preseason) |
| 01/2022 |  | Rafael Czichos | DF |  | 1. FC Köln | Köln |
| 01/2022 | | Andre Reynolds | DF |  | Memphis 901 | Memphis 901 |
| 01/2022 | | Sergio Oregel | MF |  | Chicago Fire 2 | Chicago Fire 2 |
| 01/2022 |  | Jhon Durán | FW |  | Envigado FC | Envigado |
| 01/2022 | | Missael Rodriguez | FW |  | Chicago Fire Academy | Chicago Fire Academy |
| 01/2022 |  | Ezra Hendrickson | MA |  | Columbus Crew | Columbus Crew |
| 01/2022 | | Hillary Bell | AT-C | |||
| 01/2022 | | Rubén Castro | PH-C |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2022 |  | Chinonso Offor | FW |  | CF Montréal | Montréal |
| 02/2022 |  | Johan Kappelhof | DF |  | Real Salt Lake | Salt Lake |
| 01/2022 |  | Francisco Calvo | DF |  | San Jose Earthquakes | Earthquakes |
| 01/2022 |  | Luka Stojanović | MF |  | Al Hazem | Al Hazem |
| 01/2022 | | Bobby Shuttleworth | GK |  | Atlanta United FC | Atlanta United |
| 01/2022 |  | Elliot Collier | MF |  | San Antonio FC | San Antonio FC |
| 01/2022 | | Chris Brady | GK | | Chicago Fire (Preseason) | Chicago Fire (Preseason) |
| 01/2022 | | Gabriel Słonina | GK | | Chicago Fire (Preseason) | Chicago Fire (Preseason) |
| 01/2022 | | Medrán | MF |  | Al Taawoun | Al Taawoun |
| 01/2022 |  | Ignacio Aliseda | FW |  | FC Lugano | FC Lugano |