Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 11/2021 |  | Rodrigo Venegas | MA | |||
| 08/2021 |  | Hernán Meske | MA | |||
| 07/2021 |  | Fabricio Castillo | GK | |||
| 07/2021 | | Saúl Severiche | DF |  | Blooming U20 | Club Blooming U20 |
| 07/2021 | | Fabricio Quaglio | MF | |||
| 01/2021 | | Abraham Cabrera | DF | |||
| 01/2021 | | Oscar Ribera | DF |  | Bolívar | Bolívar |
| 01/2021 | | Ricardo Pedriel | FW |  | Jorge Wilstermann | Wilstermann |
| 01/2021 | | Jorge Rojas | FW |  | Always Ready | Always Ready |
| 01/2021 | | Eduardo Villegas | MA | |||
| 01/2021 | | Santos Navarro | MF |  | Oriente Petrolero | Petrolero |
| 01/2021 | | Marco Vaca | GK | |||
| 01/2021 | | Oscar Baldomar | DF |  | Real Potosí | Real Potosí |
| 01/2021 |  | Pedro Franco | DF |  | América de Cali | América |
| 01/2021 | | Lucas Bolivia | DF | |||
| 01/2021 | | Gervasio Núñez | MF |  | Belgrano de Córdoba | Belgrano |
| 01/2021 | | Carlos Ribera | MF |  | Real Santa Cruz | Santa Cruz |
| 01/2021 |  | Juan Anangonó | FW |  | River Plate | Ríver Plate |
| 01/2021 | | Samuel Garzón | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Lucas Bolivia | DF |  | Desportiva Ferroviária - ES | Desportiva |
| 08/2021 | | Pedro Franco | DF |  | Fortaleza FC | Fortaleza |
| 08/2021 | | Erwin Sánchez | MF |  | The Strongest | The Strongest |
| 07/2021 | | Carlos Ribera | MF | | Real Santa Cruz | Santa Cruz |
| 07/2021 | | Juan Anangonó | FW |  | Comunicaciones | Comunicaciones |
| 07/2021 | | Gervasio Núñez | MF |  | Sarmiento de Junín | Sarmiento |
| 06/2021 |  | Juninho | DF |  | Barra - SC | Barra |
| 04/2021 | | Jordy Candía | DF | | Real Potosí | Real Potosí |
| 02/2021 | | José Carrasco | MF |  | Independiente del Valle | Independiente |
| 01/2021 | | Jesús Sagredo | DF | | The Strongest | The Strongest |
| 01/2021 | | Gustavo Fernández | FW |  | Laferrere | Laferrere |
| 01/2021 | | Rubén Cordano | GK | | Always Ready | Always Ready |
| 01/2021 | | Luis Vargas | MF | | Jorge Wilstermann | Wilstermann |
| 01/2021 | | César Menacho | FW | | Bolívar | Bolívar |