Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 |  | John Armijo | MA | |||
| 07/2021 |  | Héctor Adomaitis | MA | |||
| 03/2021 |  | Rodrigo de Olivera | FW |  | Montevideo City Torque | Torque |
| 03/2021 | | Felipe Flores | FW |  | Antofagasta | Antofagasta |
| 03/2021 | | Benjamin Rojas | DF |  | Palestino | Palestino |
| 03/2021 | | Franz Schultz | MF |  | Deportes Iquique | Deportes Iquique |
| 03/2021 | | Matías Blázquez | DF | | Deportes Iquique | Deportes Iquique |
| 03/2021 | | Pedro Navarro | DF |  | Colo-Colo | Colo-Colo |
| 03/2021 | | Ethan Espinoza | MF | | Colo-Colo | Colo-Colo |
| 03/2021 |  | Gaspar Di Pizio | FW |  | Estudiantes | Estudiantes |
| 03/2021 | | Sergio Arriagada | MF |  | La Serena | La Serena |
| 03/2021 | | Walter Ponce | FW | | La Serena | La Serena |
| 02/2021 | | Jaime Pizarro | MA | |||
| 01/2021 | | Ariel Leporati | MA | |||
| 01/2021 | | Cristóbal Lecaros | GK | |||
| 01/2021 | | Ignacio Ayala | DF | | Palestino | Palestino |
| 01/2021 | | Jean Durán | DF | |||
| 01/2021 | | Martín Andrade | MF | |||
| 01/2021 |  | Roger Cañas | MF | |||
| 01/2021 |  | Diego Gutiérrez | MF |  | Valour FC | Valour FC |
| 01/2021 | | Benjamín Troncoso | MF |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 | | Roberto Reyes | MF |  | Deportes Concepción | Concepción |
| 05/2021 | | Tomás Pino | DF |  | General Velásquez | CDGV |
| 05/2021 |  | José Bandez | FW |  | Deportes Copiapó | Deportes Copiapó |
| 05/2021 | | David Henríquez | FW |  | Santa Cruz | Santa Cruz |
| 03/2021 | | Leandro Garate | FW |  | Coquimbo Unido | Coquimbo Unido |
| 02/2021 | | Francisco Castro | FW |  | Cobreloa | Cobreloa |
| 02/2021 | | Mikel Arguinarena | MF |  | CD Magallanes | CD Magallanes |
| 02/2021 | | Manuel Rivera | MF |  | Ñublense | Ñublense |
| 02/2021 | | Claudio Meneses | DF |  | San Luis | San Luis |
| 02/2021 | | Juan Duma | MF |  | Deportes Melipilla | Dep. Melipilla |