Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 11/2021 |  | Samuel Arias | DF |  | Cobresal U20 | U20 |
| 09/2021 |  | Juan Vieyra | MF |  | Delfín SC | Delfín SC |
| 07/2021 | | Juan Gaete | FW |  | Colo-Colo | Colo-Colo |
| 04/2021 | | Diego González Saavedra | MF |  | O'Higgins | O'Higgins |
| 03/2021 | | José Gamonal | GK |  | Deportes Temuco | Deportes Temuco |
| 03/2021 | | Cristian Maidana | MF |  | CD Olimpia | CD Olimpia |
| 03/2021 | | Iván Smith | MF |  | Godoy Cruz II | Godoy Cruz II |
| 03/2021 | | Marcos Pol | FW |  | Everton | Everton |
| 02/2021 | | Francisco Ayala | MF |  | Puerto Montt | Puerto Montt |
| 01/2021 | | Luis Vásquez | MF | |||
| 01/2021 | | Sebastián Acevedo | GK | |||
| 01/2021 | | Alejandro Santander | GK | |||
| 01/2021 | | Carlos Bustamante | DF | |||
| 01/2021 | | Joaquín Fernández | DF | |||
| 01/2021 | | Fernando Ponce | DF |  | Alvarado | Alvarado |
| 01/2021 | | Danilo Riquelme | DF | |||
| 01/2021 | | Benjamín Romo | DF | |||
| 01/2021 | | Ignacio Pacheco | MF | |||
| 01/2021 | | Sergio Carrasco | FW | |||
| 01/2021 | | Matías Donoso | FW |  | Deportes Iquique | Deportes Iquique |
| 01/2021 |  | Brayan Hurtado | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Fernando Ponce | DF | | Deportes Temuco | Deportes Temuco |
| 03/2021 | | John Santander | DF | | Deportes Iquique | Deportes Iquique |
| 03/2021 | | Jorge Deschamps | GK |  | Rangers | Rangers |
| 03/2021 | | Marcelo Jorquera | DF |  | Unión Española | Unión Española |
| 03/2021 | | Juan Gaete | FW | | Colo-Colo | Colo-Colo |
| 02/2021 | | Ariel Coronel | DF | | Deportes Iquique | Deportes Iquique |
| 02/2021 | | Juan Gutiérrez | MF | | Deportes Temuco | Deportes Temuco |
| 02/2021 | | Facundo Castro | FW | | Deportes Temuco | Deportes Temuco |
| 01/2021 | | Alan Muriáldo | FW |  | Orense SC | Orense |