Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Emiliano Astorga | MA | |||
| 09/2021 |  | Héctor Almandoz | MA | |||
| 08/2021 |  | Gustavo Guerreño | FW |  | Deportes Melipilla | Dep. Melipilla |
| 03/2021 | | Mario Parra | DF |  | Deportes Valdivia | Valdivia |
| 03/2021 | | David Escalante | FW |  | Ñublense | Ñublense |
| 02/2021 | | Francisco Castro | FW |  | Barnechea | Barnechea |
| 02/2021 | | Daniel Vicencio | DF |  | Palestino | Palestino |
| 02/2021 | | Ronald González | MF |  | Unión Española | Unión Española |
| 02/2021 |  | Sebastián Ramírez | DF |  | Mannucci | Mannucci |
| 02/2021 | | Fernando Barrientos | MF |  | Defensa y Justicia | CSyD DyJ |
| 02/2021 | | Álvaro Césped | MF |  | San Luis | San Luis |
| 02/2021 | | Pablo Vergara | FW |  | Unión San Felipe | San Felipe |
| 02/2021 | | Rodrigo Meléndez | MA | |||
| 01/2021 | | Nicolás Palma | DF | |||
| 01/2021 | | Bryan Cortés | MF | |||
| 01/2021 | | Fernando Lazcano | MF |  | Curicó Unido | Curicó Unido |
| 01/2021 | | Javier Meléndez | MF | |||
| 01/2021 | | Nicolás Orrego | MF | |||
| 01/2021 | | Fabian Quilaleo | MF | |||
| 01/2021 | | Christopher Retamal | MF | |||
| 01/2021 | | Bastian Valdés | MF | |||
| 01/2021 | | Leonardo Olivera | FW |  | Cobresal | CD Cobresal |
| 01/2021 | | Luciano Parra | FW | |||
| 01/2021 | | Patricio Romero | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Pablo Vergara | FW |  | Santiago Morning | Morning |
| 03/2021 | | José Contreras | DF |  | Deportes Copiapó | Deportes Copiapó |
| 03/2021 | | Matías Fernández | MF | | Deportes Valdivia | Valdivia |
| 02/2021 | | Kilian Delgado | FW |  | San Marcos | San Marcos |
| 02/2021 | | Eric Ahumada | DF |  | Antofagasta | Antofagasta |
| 02/2021 | | Juan Andrade | DF |  | Puerto Montt | Puerto Montt |
| 02/2021 | | Claudio Jopia | DF |  | CD Magallanes | CD Magallanes |
| 02/2021 | | José Monreal | FW |  | Rangers | Rangers |
| 01/2021 | | Maximiliano Cuadra | FW |  | Racing Club | Racing Club |