Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 02/2022 |  | Chahid el Allachi | MF |  | PSV Eindhoven U18 | U18 |
| 02/2022 | | Dylan Hopman | MF | | PSV Eindhoven U18 | U18 |
| 02/2022 | | Sven Simons | MF | | PSV Eindhoven U18 | U18 |
| 01/2022 | | D'Leanu Arts | DF | | PSV Eindhoven U18 | U18 |
| 01/2022 | | Jesse Giebels | DF | | PSV Eindhoven U18 | U18 |
| 01/2022 | | Julian Kuijpers | DF | | PSV Eindhoven U18 | U18 |
| 11/2021 |  | Matteo Dams | DF |  | PSV Eindhoven U19 | Eindhoven U19 |
| 11/2021 |  | August Priske | FW | | PSV Eindhoven U18 | U18 |
| 09/2021 |  | Maxi Romero | FW |  | PSV Eindhoven | PSV Eindhoven |
| 08/2021 |  | Yunus Bahadir | DF |  | Sporting Charleroi | Charleroi SC |
| 08/2021 |  | Simon Colyn | MF |  | Vancouver Whitecaps | Vancouver |
| 08/2021 |  | Nathan Markelo | DF |  | Everton FC U21 | Everton FC U21 |
| 08/2021 | | Niek Schiks | GK | | PSV Eindhoven | PSV Eindhoven |
| 08/2021 |  | Dante Sealy | FW |  | FC Dallas | FC Dallas |
| 07/2021 | | Tyrick Bodak | GK | | PSV Eindhoven U18 | U18 |
| 07/2021 | | Youri Roulaux | GK |  | Roda JC Kerkrade | Roda JC |
| 07/2021 | | Ruud van Nistelrooy | MA | | PSV Eindhoven U18 | U18 |
| 07/2021 |  | Adil Ramzi | AS-CO |  | PSV Eindhoven U17 | Eindhoven U17 |
| 07/2021 | | Tim Wolf | AS-CO | | PSV Eindhoven U18 | U18 |
| 07/2021 | | Abe Knoop | GK-CO |  | VV Capelle | Capelle |
| 07/2021 | | Koen Berkheij | G-AN |  | ADO Den Haag | ADO Den Haag |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 | | Emmanuel Matuta | MF |  | FC Groningen | Groningen |
| 08/2021 | | Robin Schoonbrood | MF | | Roda JC Kerkrade | Roda JC |
| 07/2021 | | Kyan van Dorp | GK |  | FC Emmen | FC Emmen |
| 07/2021 | | Tijn Daverveld | DF |  | AEL Limassol | AEL Limassol |
| 07/2021 | | Jamal Gonzaga | MF | | PSV Eindhoven U18 | U18 |
| 07/2021 | | Naïm Matoug | MF |  | Willem II U21 | U21 |
| 07/2021 | | Dante Rigo | MF | | PSV Eindhoven | PSV Eindhoven |
| 07/2021 |  | Kristófer Kristinsson | FW |  | Grenoble Foot 38 | Grenoble |
| 07/2021 | | Peter Uneken | MA |  | RKC Waalwijk | RKC Waalwijk |
| 07/2021 | | Wilfred Bouma | AS-CO | | PSV Eindhoven U18 | U18 |
| 07/2021 | | Albert van der Sleen | GK-CO | | PSV Eindhoven U18 | U18 |