Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Alvas Powell | DF |  | Philadelphia Union | Philadelphia |
| 12/2021 |  | Alec Kann | GK |  | Atlanta United FC | Atlanta United |
| 12/2021 | | Pat Noonan | MA | | Philadelphia Union | Philadelphia |
| 09/2021 | | Tyrone Marshall | MA |  | FC Cincinnati U19 | U19 |
| 09/2021 |  | Scott Armistead | AT-C |  | FC Tucson | FC Tucson |
| 08/2021 | | Kyle Scott | MF |  | Newcastle United U21 | Newcastle U21 |
| 08/2021 |  | Ben Lundt | GK |  | Phoenix Rising | Phoenix |
| 08/2021 | | Chris Duvall | DF | |||
| 08/2021 |  | Tyler Blackett | DF |  | Nottingham Forest | Nott'm Forest |
| 08/2021 |  | Florian Valot | MF |  | New York RB II | New York RB II |
| 07/2021 |  | Arquimides Ordóñez | FW |  | FC Cincinnati 2 | FC Cincinnati 2 |
| 05/2021 | | Geoff Cameron | DF |  | Queens Park Rangers | QPR |
| 05/2021 |  | Kenneth Vermeer | GK |  | Los Angeles FC | Los Angeles |
| 04/2021 | | Edgar Castillo | DF | |||
| 04/2021 |  | Gustavo Vallecilla | DF |  | Aucas | SD Aucas |
| 03/2021 |  | Isaac Atanga | FW |  | FC Nordsjælland | Nordsjælland |
| 03/2021 |  | Luciano Acosta | MF |  | Atlas Guadalajara | Atlas |
| 02/2021 |  | Brenner | FW |  | São Paulo FC | São Paulo FC |
| 01/2021 | | Avionne Flanagan | DF | |||
| 01/2021 |  | Jonas Fjeldberg | FW |  | Dayton Flyers | Dayton Flyers |
| 01/2021 | | Calvin Harris | FW |  | Wake Forest Demon Deacons | Wake Forest |
| 01/2021 | | Cody Cropper | GK |  | Houston Dynamo | H. Dynamo |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 | | Cody Cropper | GK |  | Memphis 901 | Memphis 901 |
| 08/2021 | | Jonas Fjeldberg | FW |  | Rio Grande Valley FC | RGV FC |
| 08/2021 |  | Tom Pettersson | DF |  | Lillestrøm SK | LSK |
| 08/2021 | | Ben Mines | MF |  | Orange County SC | Orange County |
| 07/2021 |  | Franko Kovačević | FW |  | Pafos FC | Pafos FC |
| 07/2021 |  | Jürgen Locadia | FW |  | Brighton & Hove Albion | Brighton & Hove |
| 05/2021 | | Avionne Flanagan | DF | | Orange County SC | Orange County |
| 05/2021 | | Ben Lundt | GK | | Phoenix Rising | Phoenix |
| 04/2021 | | Franuel Amaya | MF |  | New York RB | New York RB |
| 02/2021 | | Bobby Edwards | GK |  | Indy Eleven | Indy Eleven |
| 01/2021 |  | Kendall Waston | DF |  | Deportivo Saprissa | Saprissa |
| 01/2021 | | Siem de Jong | MF |  | Sc Heerenveen | Heerenveen |
| 01/2021 | | Andrew Gutman | DF |  | Celtic FC | Celtic |
| 01/2021 | | Tommy McCabe | MF | | Orange County SC | Orange County |
| 01/2021 | | Jimmy McLaughlin | MF |  | Louisville City FC | LouCity |