Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 03/2022 |  | Dirk Baron | GK |  | FC Groningen U21 | U21 |
| 01/2022 |  | Emmanuel Matuta | MF |  | Jong PSV | Jong PSV |
| 01/2022 | | Melayro Bogarde | MF |  | TSG Hoffenheim | Hoffenheim |
| 01/2022 | | Harmen Kuperus | GK-CO |  | Fortuna Sittard | Fortuna Sittard |
| 10/2021 |  | Alex Mortensen | FW | | FC Groningen U21 | U21 |
| 09/2021 | | Owen van der Vlag | GK | | FC Groningen U21 | U21 |
| 09/2021 | | Elias Olsson | DF | | FC Groningen U21 | U21 |
| 08/2021 |  | Yahya Kalley | DF |  | IFK Göteborg U21 | U21 |
| 08/2021 |  | Laros Duarte | MF |  | Sparta Rotterdam | Sp. Rotterdam |
| 08/2021 |  | Daleho Irandust | MF |  | BK Häcken | BK Häcken |
| 08/2021 |  | Sebastian Tounekti | FW |  | FK Bodø/Glimt | Bodø/Glimt |
| 07/2021 | | Cyril Ngonge | FW |  | RKC Waalwijk | RKC Waalwijk |
| 07/2021 | | Jan Hoekstra | GK |  | Roda JC Kerkrade | Roda JC |
| 07/2021 | | Peter Leeuwenburgh | GK |  | Cape Town City FC | Cape Town City FC |
| 07/2021 |  | Radinio Balker | DF |  | Almere City FC | Almere City FC |
| 07/2021 | | Neraysho Kasanwirjo | DF |  | Jong Ajax | Ajax (J) |
| 07/2021 | | Thomas Poll | DF |  | FC Dordrecht | Dordrecht |
| 07/2021 |  | Marin Šverko | DF |  | 1. FC Saarbrücken | Saarbrücken |
| 07/2021 | | Michael de Leeuw | FW |  | FC Emmen | FC Emmen |
| 07/2021 | | Romano Postema | FW |  | FC Den Bosch | FC Den Bosch |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 | | Wessel Dammers | DF |  | Willem II | Willem II |
| 01/2022 | | Patrick Joosten | FW |  | SC Cambuur | SC Cambuur |
| 01/2022 |  | Sascha Marth | GK-CO |  | Lokomotiv Moscow | Lok Moscow |
| 01/2022 | | Elias Olsson | DF |  | Kalmar FF | Kalmar FF |
| 09/2021 |  | Ahmed El Messaoudi | MF |  | Gaziantep FK | Gaziantep |
| 08/2021 | | Gabriel Gudmundsson | DF |  | Lille OSC | Lille |
| 08/2021 | | Thomas Poll | DF | | Almere City FC | Almere City FC |
| 08/2021 | | Azor Matusiwa | MF |  | Stade de Reims | Stade Reims |
| 07/2021 |  | Per Kristian Bråtveit | GK |  | Nîmes Olympique | Nîmes |
| 07/2021 | | Sergio Padt | GK |  | PFC Ludogorets Razgrad | Ludogorets |
| 07/2021 |  | Kō Itakura | DF |  | Manchester City | Man City |
| 07/2021 | | Leonel Miguel | DF | | FC Emmen | FC Emmen |
| 07/2021 |  | Miguel Leal | DF |  | Villarreal CF B | Villarreal B |
| 07/2021 | | Tika de Jonge | MF | | FC Groningen U21 | U21 |
| 07/2021 | | Luciano Valente | MF | | FC Groningen U21 | U21 |
| 07/2021 | | Alessio Da Cruz | FW |  | Parma Calcio 1913 | Parma |
| 07/2021 | | Thijs Dallinga | FW |  | SBV Excelsior | Excelsior |
| 07/2021 | | Kian Slor | FW | | FC Groningen U21 | U21 |
| 07/2021 | | Joël van Kaam | FW | | FC Groningen U21 | U21 |