Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2022 |  | Ignacio Pintos | MF | |||
| 07/2022 |  | Bruno Vides | FW |  | Huracán | Huracán |
| 07/2022 | | Francisco Martinicorena | FW | |||
| 07/2022 | | Lucas Monzón | DF |  | New York RB | New York RB |
| 07/2022 | | Bryan Olivera | MF |  | Peñarol | Peñarol |
| 07/2022 | | Aaron Spetale | FW |  | Estudiantes | Estudiantes |
| 04/2022 | | Franco González | MF |  | Danubio U20 | U20 |
| 01/2022 | | Gerónimo Bortagaray | DF |  | Montevideo Wanderers | Wanderers |
| 01/2022 | | Lucas Ferreira | DF |  | Progreso | Progreso |
| 01/2022 | | Cristian González | DF |  | Central Español | Español |
| 01/2022 | | Rodrigo Corbo | MF | | Danubio U20 | U20 |
| 01/2022 | | Walter Corrales | MF |  | Rampla Juniors | Rampla Juniors |
| 01/2022 | | Cristian Cruz | MF |  | Cerrito | Cerrito |
| 01/2022 | | Franco Macchi | MF |  | Rocha | Rocha |
| 01/2022 | | Juan Millán | MF |  | Racing | Racing |
| 01/2022 | | Leandro Navarro | MF |  | Alvarado | Alvarado |
| 01/2022 | | Denis Olivera | MF |  | Villa Española | Española |
| 01/2022 | | Nicolás Rodríguez | MF |  | River Plate | River Plate |
| 01/2022 |  | Jimmy Evans | FW | | Rocha | Rocha |
| 01/2022 | | Sebastián Fernández | FW |  | Liverpool | Liverpool FC |
| 01/2022 | | Guillermo May | FW |  | Nacional | Nacional |
| 01/2022 | | Santiago Paiva | FW |  | Cerro Largo | Cerro Largo |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 | | Maicol Cabrera | FW | | Huracán | Huracán |
| 07/2022 | | Santiago Paiva | FW |  | Godoy Cruz | Godoy Cruz |
| 02/2022 | | Maximiliano Rodríguez | MF |  | Sud América | Sud América |
| 02/2022 | | Fredy Martínez | DF | | Villa Española | Española |
| 02/2022 | | Cristian González | DF |  | Rentistas | Rentistas |
| 01/2022 | | Enzo Siri | DF | | Cerrito | Cerrito |
| 01/2022 | | Matías Fritzler | MF |  | Agropecuario Argentino | Agropecuario |
| 01/2022 | | Santiago Carrera | DF | | Sud América | Sud América |
| 01/2022 | | Maxi Añasco | MF | | Sud América | Sud América |
| 01/2022 | | Jorge Gravi | MF |  | Atenas | Atenas |
| 01/2022 | | Maximiliano Lemos | MF |  | Miramar Misiones | Misiones |
| 01/2022 | | Javier Méndez | MF |  | Independiente Medellín | Medellín |
| 01/2022 | | Luis Acevedo | FW | | Rentistas | Rentistas |
| 01/2022 | | Martín Comachi | FW |  | All Boys | All Boys |
| 01/2022 | | Matías Deorta | FW |  | Durazno | Durazno |