Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 |  | Emanuel Hernández | DF |  | Sud América | Sud América |
| 08/2021 | | Martín Rea | DF | |||
| 08/2021 | | Wiston Fernández | MF |  | Boston River | Boston River |
| 08/2021 | | Diego Vicente | MF |  | River Plate | River Plate |
| 08/2021 | | Jorge Fossati | MA | |||
| 08/2021 | | Maicol Cabrera | FW |  | CA Cerro | CA Cerro |
| 05/2021 | | Maximiliano Lemos | MF |  | Rentistas | Rentistas |
| 04/2021 | | Martin Ripoll | AT-C | | River Plate | River Plate |
| 04/2021 | | Luis Acevedo | FW |  | Peñarol | Peñarol |
| 04/2021 | | Juan Manuel Olivera | FW | | River Plate | River Plate |
| 04/2021 | | Jorge Gravi | MF |  | Plaza Colonia | Plaza Colonia |
| 04/2021 | | Esteban Conde | GK |  | Atenas | Atenas |
| 04/2021 | | Ribair Rodríguez | MF | | River Plate | River Plate |
| 04/2021 | | Ignacio González | MF |  | Montevideo Wanderers | Wanderers |
| 04/2021 | | José Río | GK | |||
| 01/2021 | | Mateo Ponte | DF | |||
| 01/2021 | | Rafael Haller | DF |  | Danubio U20 | U20 |
| 01/2021 | | Nahuel Segovia | DF | |||
| 01/2021 | | Maxi Añasco | MF | | Danubio U20 | U20 |
| 01/2021 | | Lucas Dogliotti | MF | |||
| 01/2021 | | Leandro Onetto | MF |  | Villa Teresa | Villa Teresa |
| 01/2021 | | Facundo Saravia | MF | |||
| 01/2021 | | Santiago Silva | MF | |||
| 01/2021 | | Emiliano García | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | José Luis Rodríguez | DF |  | Fénix | Fénix |
| 07/2021 |  | Emanuel Mercado | FW |  | Almagro | Almagro |
| 05/2021 | | Pablo Siles | MF |  | Vitória - BA | EC Vitória |
| 04/2021 | | Cristian González | DF |  | Central Español | Español |
| 04/2021 | | Franco Macchi | MF |  | Rocha | Rocha |
| 04/2021 | | Matías Jones | MF | | Central Español | Español |
| 04/2021 | | Santiago Paiva | FW |  | Cerro Largo | Cerro Largo |
| 04/2021 | | Salvador Ichazo | GK | | River Plate | River Plate |
| 04/2021 | | Lucas Monzón | DF | | Montevideo Wanderers | Wanderers |
| 03/2021 | | Leandro Onetto | MF | | Cerro Largo | Cerro Largo |
| 02/2021 |  | Julio Domínguez | DF |  | Manta | Manta |
| 02/2021 | | Nicolás Prieto | MF | | Manta | Manta |
| 02/2021 | | Rodrigo Piñeiro | FW |  | Nashville SC | Nashville SC |
| 01/2021 | | Nicolás Pantaleone | DF |  | Tristan Suárez | Tristan Suárez |
| 01/2021 | | Lucas Rodríguez | MF |  | Mannucci | Mannucci |