Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 |  | Santiago Giordana | FW |  | Chacarita Juniors | Chacarita |
| 07/2021 |  | José Monaga | DF |  | El Nacional | El Nacional |
| 03/2021 | | Rody Zambrano | DF |  | Clan Juvenil | CD Clan Juvenil |
| 02/2021 | | Jonathan Capuz | MF | |||
| 02/2021 |  | Ricardo Adé | DF |  | CD Magallanes | CD Magallanes |
| 02/2021 |  | Jacobo Kouffati | FW | |||
| 01/2021 | | Harrinson Flores | DF |  | 9 de Octubre | 9 de Octubre |
| 01/2021 | | Jonathan Bauman | FW |  | Quilmes | Quilmes |
| 01/2021 | | Wilman Pabón | GK | |||
| 01/2021 | | Jean Estacio | MF | |||
| 01/2021 | | Wilter Ayoví | FW | |||
| 01/2021 | | Gabino Bolaños | FW |  | Mushuc Runa U19 | U19 |
| 01/2021 | | César Obando | DF |  | América de Quito | América |
| 01/2021 | | Bagner Delgado | MF |  | Olmedo | Olmedo |
| 01/2021 | | Carlos Feraud | MF |  | Macará | Macará |
| 01/2021 |  | Gonzalo Jara | MF |  | Progreso | Progreso |
| 01/2021 | | Juan Nazareno | MF | | 9 de Octubre | 9 de Octubre |
| 01/2021 | | William Ocles | MF | |||
| 01/2021 |  | Cristian Palomeque | MF |  | Alianza FC | Alianza |
| 01/2021 | | José Ayoví | FW |  | Guayaquil City | Guayaquil |
| 01/2021 | | Oscar Jaramillo | FW | | América de Quito | América |
| 01/2021 | | Miguel Murillo | FW |  | Águilas Doradas | Águilas |
| 01/2021 | | Geovanny Cumbicus | MA | | Olmedo | Olmedo |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 | | Jonathan Bauman | FW |  | Independiente del Valle | Independiente |
| 04/2021 | | Jhon Carabalí | FW |  | Alianza de Guano | Alianza |
| 02/2021 | | Leonardo Incorvaia | DF |  | Isidro Metapán | Metapán |
| 02/2021 | | Julio Angulo | FW |  | Orense SC | Orense |
| 01/2021 | | Muriel Orlando | FW | | Macará | Macará |
| 01/2021 | | Iván Brun | GK |  | San Telmo | San Telmo |
| 01/2021 | | Ángel Castillo | DF |  | Atlético Porteño | Atlético Porteño |
| 01/2021 | | Armando Gómez | DF |  | Chacaritas FC | Chacaritas FC |
| 01/2021 | | Ronny Rueda | DF | | Chacaritas FC | Chacaritas FC |
| 01/2021 | | Dario Bone | MF |  | Técnico Universitario | Técnico |
| 01/2021 | | Franco Faría | MF |  | Central Norte | Central Norte |
| 01/2021 | | Horacio Orzán | MF |  | FBC Melgar | FBC Melgar |
| 01/2021 | | Ignacio Herrera | FW |  | Aucas | SD Aucas |