Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 03/2022 |  | Vicente Sánchez | AS-CO | |||
| 01/2022 |  | Mauricio Isais | DF |  | CF Pachuca U20 | U20 |
| 01/2022 |  | Fernando Navarro | DF |  | Club León | Club León |
| 01/2022 |  | Geisson Perea | DF |  | Atlético Nacional | Atl. Nacional |
| 01/2022 | | Pedro Pedraza | MF |  | Mineros de Zacatecas | Zacatecas |
| 01/2022 | | Jesús Trindade | MF |  | Peñarol | Peñarol |
| 12/2021 | | Guillermo Almada | MA |  | Santos Laguna | Santos Laguna |
| 12/2021 | | Darwin Quintana | AS-CO | |||
| 07/2021 | | Fernando Álvarez | DF | | CF Pachuca U20 | U20 |
| 07/2021 | | Alán Bautista | MF | | CF Pachuca U20 | U20 |
| 07/2021 | | Pablo López | MF |  | Atlético San Luis | San Luis |
| 07/2021 | | Héctor Mascorro | MF | | Mineros de Zacatecas | Zacatecas |
| 07/2021 | | Yairo Moreno | MF | | Club León | Club León |
| 07/2021 | | Luis Soto | MF |  | Cruz Azul Hidalgo | Cruz Azul |
| 07/2021 | | Illian Hernández | FW | | CF Pachuca U20 | U20 |
| 07/2021 | | Jesús Hernández | FW | | CF Pachuca U20 | U20 |
| 07/2021 | | Avilés Hurtado | FW |  | CF Monterrey | CF Monterrey |
| 07/2021 |  | Nicolás Ibáñez | FW | | Atlético San Luis | San Luis |
| 07/2021 | | Mauricio Marchetti | PH-C |  | River Plate | River Plate |
| 07/2021 | | Kevin Hernández | G-AN |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 |  | Matías Catalán | DF |  | Talleres de Córdoba | Talleres |
| 01/2022 | | Jorge Hernández | MF |  | Gallos Blancos | Querétaro |
| 01/2022 | | Francisco Figueroa | FW | | Gallos Blancos | Querétaro |
| 01/2022 | | Illian Hernández | FW | | CF Pachuca U20 | U20 |
| 08/2021 | | Héctor Mascorro | MF |  | Atlético San Luis U20 | U20 |
| 07/2021 | | José Eulogio | GK | | CF Pachuca U20 | U20 |
| 07/2021 | | Carlos Rodas | GK | | CF Pachuca U20 | U20 |
| 07/2021 | | Emmanuel García | DF | | Atlético San Luis | San Luis |
| 07/2021 | | Érick Aguirre | MF | | CF Monterrey | CF Monterrey |
| 07/2021 | | Efraín Orona | MF | | Atlético San Luis | San Luis |
| 07/2021 | | Felipe Pardo | MF |  | Deportivo Toluca | Toluca |
| 07/2021 | | Luis Calzadilla | FW | | Atlético San Luis | San Luis |
| 07/2021 | | Bruce El-mesmari | FW |  | Las Vegas Lights FC | Las Vegas Lights FC |
| 07/2021 | | Eduardo Mustre | FW | | CF Pachuca U20 | U20 |
| 07/2021 |  | Roberto Nurse | FW |  | Coyotes de Tlaxcala | Tlaxcala |
| 07/2021 | | Mauro Quiroga | FW |  | Club Necaxa | Necaxa |