| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 18.07.2010 | Matchday 1 | Matchday 1 | A | ![]() | Indios | L | 1:5 |
| 25.07.2010 | Matchday 2 | Matchday 2 | H | ![]() | Club Tijuana | D | 0:0 |
| 31.07.2010 | Matchday 3 | Matchday 3 | A | ![]() | UdeG | D | 2:2 |
| 09.08.2010 | Matchday 4 | Matchday 4 | H | ![]() | San Luis | L | 0:2 |
| 16.08.2010 | Matchday 5 | Matchday 5 | H | ![]() | Cafetaleros | D | 2:2 |
| 22.08.2010 | Matchday 6 | Matchday 6 | A | ![]() | Club León | W | 3:2 |
| 29.08.2010 | Matchday 7 | Matchday 7 | H | ![]() | Dorados | D | 1:1 |
| 12.09.2010 | Matchday 8 | Matchday 8 | A | ![]() | Venados FC | D | 1:1 |
| 19.09.2010 | Matchday 9 | Matchday 9 | H | ![]() | Alacranes | D | 0:0 |
| 26.09.2010 | Matchday 10 | Matchday 10 | A | ![]() | Albinegros Orizaba | L | 1:2 |
| 03.10.2010 | Matchday 11 | Matchday 11 | H | ![]() | Lobos | W | 1:0 |
| 10.10.2010 | Matchday 12 | Matchday 12 | A | ![]() | Correcaminos | W | 1:0 |
| 16.10.2010 | Matchday 13 | Matchday 13 | H | ![]() | Cruz Azul | W | 1:0 |
| 23.10.2010 | Matchday 14 | Matchday 14 | A | ![]() | Pumas Morelos | D | 0:0 |
| 30.10.2010 | Matchday 15 | Matchday 15 | H | ![]() | CD Irapuato | L | 1:2 |
| 07.11.2010 | Matchday 16 | Matchday 16 | A | ![]() | Potros Neza | W | 2:1 |
| 13.11.2010 | Matchday 17 | Matchday 17 | H | ![]() | CD Veracruz | W | 2:1 |
Guerreros Hermosillo

















