Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Guzman Montgomery | G-AN | |||
| 09/2021 | | Leandro Méndez | MF | |||
| 09/2021 | | Ramiro Méndez | GK | |||
| 08/2021 | | Marco Mancebo | DF |  | Defensor Sporting | Defensor |
| 08/2021 | | Agustín Dávila | FW |  | Peñarol | Peñarol |
| 08/2021 | | Nicolás González | FW |  | River Plate | River Plate |
| 08/2021 | | Guzmán Rodríguez | DF | | River Plate | River Plate |
| 08/2021 | | Damián Silva | MF | | Defensor Sporting | Defensor |
| 08/2021 | | Gonzalo Bueno | FW | | Defensor Sporting | Defensor |
| 07/2021 | | Pablo Furtado | MF | |||
| 06/2021 | | Ignacio Ithurralde | MA | |||
| 06/2021 | | Fabián Yantorno | AS-CO | |||
| 04/2021 | | Martín Fernández | MF |  | CA Cerro | CA Cerro |
| 04/2021 | | Gastón Álvarez | DF | | Defensor Sporting | Defensor |
| 04/2021 | | Álex de Freitas | DF |  | Deportivo Maldonado | Maldonado |
| 04/2021 | | Christian Pintado | MF |  | Tacuarembó | Tacuarembó |
| 04/2021 | | Alan Rodríguez | MF | | Defensor Sporting | Defensor |
| 04/2021 | | Facundo Labandeira | FW |  | Danubio | Danubio |
| 04/2021 | | Alexander Machado | FW | | CA Cerro | CA Cerro |
| 04/2021 | | Maximiliano Pérez | FW |  | Alianza FC | Alianza |
| 03/2021 | | Lucas Villalba | MF |  | Boston River U20 | U20 |
| 02/2021 | | Mathías Tomás | MF |  | Juventud de Las Piedras | Juventud |
| 01/2021 |  | Matías Sosa | MF |  | Talleres (RdE) | Talleres |
| 01/2021 | | Juan Moreira | FW |  | Villa Española | Española |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 | | Sebastián Gorga | DF |  | Central Español | Español |
| 08/2021 | | Wiston Fernández | MF | | Danubio | Danubio |
| 08/2021 | | Luciano Olaizola | MF |  | Progreso | Progreso |
| 08/2021 | | Juan Moreira | FW |  | Racing | Racing |
| 08/2021 | | Rubén Bentancourt | FW | | Peñarol | Peñarol |
| 07/2021 | | Mauricio Fratta | GK |  | Rocha | Rocha |
| 04/2021 | | Santiago Arias | MF | | Progreso | Progreso |
| 04/2021 | | Robert Flores | MF | | Villa Española | Española |
| 04/2021 | | Nicolás Barán | DF |  | Sud América | Sud América |
| 04/2021 | | Diego Gurri | MF | | Progreso | Progreso |
| 04/2021 | | Brian Leis | FW |  | Uruguay Montevideo | Uru Montevideo |
| 03/2021 | | Matías Rigoleto | FW |  | San Luis | San Luis |
| 03/2021 |  | Weverton | DF |  | Rio Branco - ES | Rio Branco |
| 03/2021 | | Matías Sosa | MF | | Talleres (RdE) | Talleres |
| 01/2021 | | Emiliano Álvarez | DF | | Defensor Sporting | Defensor |
| 01/2021 |  | Dany Cure | FW |  | Deportivo La Guaira | Deportivo La Guaira |