| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 14.08.2011 | Matchday 1 | Matchday 1 | A | ![]() | CA Cerro | L | 1:31:0 |
| 21.08.2011 | Matchday 2 | Matchday 2 | H | ![]() | Racing | D | 0:00:0 |
| 28.08.2011 | Matchday 3 | Matchday 3 | A | ![]() | Defensor | D | 1:10:1 |
| 03.09.2011 | Matchday 4 | Matchday 4 | H | ![]() | El Tanque | L | 0:10:1 |
| 11.09.2011 | Matchday 5 | Matchday 5 | A | ![]() | Bella Vista | W | 1:01:0 |
| 18.09.2011 | Matchday 6 | Matchday 6 | H | ![]() | River Plate | D | 0:00:0 |
| 25.09.2011 | Matchday 7 | Matchday 7 | A | ![]() | Danubio | L | 0:10:1 |
| 01.10.2011 | Matchday 8 | Matchday 8 | H | ![]() | Nacional | L | 0:30:1 |
| 09.10.2011 | Matchday 9 | Matchday 9 | A | ![]() | Rampla Juniors | W | 3:12:0 |
| 16.10.2011 | Matchday 10 | Matchday 10 | H | ![]() | Cerro Largo | D | 0:00:0 |
| 06.11.2011 | Matchday 11 | Matchday 11 | H | ![]() | Rentistas | W | 1:00:0 |
| 12.11.2011 | Matchday 12 | Matchday 12 | A | ![]() | Fénix | L | 1:30:2 |
| 19.11.2011 | Matchday 13 | Matchday 13 | A | ![]() | Wanderers | L | 1:30:1 |
| 26.11.2011 | Matchday 14 | Matchday 14 | H | ![]() | Liverpool FC | L | 1:20:0 |
| 03.12.2011 | Matchday 15 | Matchday 15 | H | ![]() | Peñarol | L | 0:50:1 |
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