Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2022 |  | Maximiliano Viera | FW |  | Atenas | Atenas |
| 08/2022 | | Carlos Canobbio | MA |  | Basáñez | Basáñez |
| 07/2022 | | Diego Guastavino | MF | | Atenas | Atenas |
| 07/2022 | | Nahuel Da Silva | FW | |||
| 07/2022 | | Franco López | FW | |||
| 06/2022 | | Martín Rivas | DF | |||
| 03/2022 | | Luciano Olaizola | MF |  | Boston River | Boston River |
| 03/2022 | | Jonathan Soto | FW |  | Rocha | Rocha |
| 02/2022 |  | Gonzalo Jara | MF |  | Mushuc Runa | Mushuc Runa |
| 02/2022 | | Luis Femia | MF | |||
| 01/2022 | | Ramiro Bentancur | GK |  | Cerro Largo | Cerro Largo |
| 01/2022 | | Nahuel Furtado | DF | | Atenas | Atenas |
| 01/2022 | | Matías González | DF |  | Rangers | Rangers |
| 01/2022 | | Hernán Labraga | DF |  | Montevideo Wanderers | Wanderers |
| 01/2022 | | Richard Rodríguez | DF |  | Central Español | Español |
| 01/2022 | | Ismael Tejería | DF | | Boston River | Boston River |
| 01/2022 | | Gabriel Albín | MF |  | Villa Española | Española |
| 01/2022 | | Nicolás Freitas | MF | | Boston River | Boston River |
| 01/2022 | | Alejandro García | MF | |||
| 01/2022 | | Mario García | MF |  | Rentistas | Rentistas |
| 01/2022 | | Facundo Gonzalez | MF | |||
| 01/2022 | | Joel Lew | MF |  | Rampla Juniors | Rampla Juniors |
| 01/2022 | | Agustín Moreira | MF | |||
| 01/2022 | | Federico Millacet | FW |  | San Marcos | San Marcos |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 | | Richard Rodríguez | DF | | Central Español | Español |
| 06/2022 | | Federico Millacet | FW |  | Gualaceo SC | Gualaceo SC |
| 02/2022 |  | Joaquín Gottesman | MF |  | Sud América | Sud América |
| 01/2022 | | Fabián Vargas | DF | | Basáñez | Basáñez |
| 01/2022 | | Jonathan Barboza | MF |  | Irodotos | Irodotos |
| 01/2022 | | Rodrigo Formento | GK |  | Coquimbo Unido | Coquimbo Unido |
| 01/2022 | | Bryan Bentaberry | DF | | Cerro Largo | Cerro Largo |
| 01/2022 | | Lucas Ferreira | DF |  | Danubio | Danubio |
| 01/2022 | | Lucas Morales | DF | | Cerro Largo | Cerro Largo |
| 01/2022 | | Alex Silva | DF |  | Deportivo Maldonado | Maldonado |
| 01/2022 | | Gonzalo Andrada | MF |  | Defensor Sporting | Defensor |
| 01/2022 | | Santiago Arias | MF |  | Alianza Atlético | Alianza Atlétic |
| 01/2022 | | Nahuel Fagian | MF |  | Montevideo City Torque | Torque |
| 01/2022 | | Luciano Olaizola | MF | | Boston River | Boston River |
| 01/2022 | | Christian Paiva | MF | | Rampla Juniors | Rampla Juniors |
| 01/2022 | | Andrés Romero | MF | | Cerro Largo | Cerro Largo |
| 01/2022 | | Gustavo Alles | FW | | Gualaceo SC | Gualaceo SC |
| 01/2022 | | Alexander Rosso | FW | | Villa Española | Española |
| 01/2022 | | Maximiliano Viera | FW | | Atenas | Atenas |