Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 |  | Ronald Gil | DF | |||
| 07/2022 | | Mauricio Cabral | MF | |||
| 07/2022 |  | Martín Alaníz | FW |  | Orense SC | Orense |
| 07/2022 |  | Padu | FW | |||
| 07/2022 |  | Rodrigo Ruiz Diaz | FW |  | Resistencia SC | Resistencia |
| 03/2022 | | Harry Céspedes | DF |  | Bolívar | Bolívar |
| 03/2022 | | Mauricio Soria | MA | |||
| 01/2022 | | Élder Arauz | GK |  | Independiente Petrolero | Independiente |
| 01/2022 | | Walter Antelo | DF |  | Royal Pari | Royal Pari |
| 01/2022 | | David Robles | DF |  | Real Tomayapo | Tomayapo |
| 01/2022 | | Brahian Égüez | MF |  | Real Santa Cruz | Santa Cruz |
| 01/2022 | | Layonel Figueroa | MF | | Royal Pari | Royal Pari |
| 01/2022 | | Alejandro Meleán | MF |  | Jorge Wilstermann | Wilstermann |
| 01/2022 | | José Rodríguez | MF | |||
| 01/2022 | | Juan Godoy | FW | | Independiente Petrolero | Independiente |
| 01/2022 |  | Luis Leal | FW |  | Sol de América | Sol de América |
| 01/2022 | | Juan Montenegro | FW |  | Oriente Petrolero | Petrolero |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 | | Juan Godoy | FW | | Independiente Petrolero | Independiente |
| 02/2022 |  | Heber Leaños | DF |  | San Martín de Burzaco | San Martín |
| 01/2022 | | Saidt Mustafá | GK |  | Nacional Potosí | Nacional Potosí |
| 01/2022 | | Martín Galain | DF | | Nacional Potosí | Nacional Potosí |
| 01/2022 | | Juan Mercado | DF | | Oriente Petrolero | Petrolero |
| 01/2022 | | Anderson Góngora | MF |  | Universitario de Vinto | Universitario de Vinto |
| 01/2022 | | Luis Melgar | MF | | Oriente Petrolero | Petrolero |
| 01/2022 |  | Bruno Pascua | MF | | Real Tomayapo | Tomayapo |
| 01/2022 | | William Álvarez | FW | | Nacional Potosí | Nacional Potosí |
| 01/2022 | | Mauricio Chajtur | FW | | Real Tomayapo | Tomayapo |
| 01/2022 | | Alan Mercado | FW | | Real Santa Cruz | Santa Cruz |
| 01/2022 |  | John Mosquera | FW |  | Sporting Cristal | Sp. Cristal |