Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 |  | Mateo Piedra | DF |  | Deportivo Cuenca | Cuenca |
| 07/2021 | | Orlando Herrera | DF |  | Independiente del Valle U20 | U20 |
| 07/2021 | | Patrik Mercado | MF | | Independiente del Valle U20 | U20 |
| 07/2021 | | Yaimar Medina | MF | | Independiente del Valle U20 | U20 |
| 06/2021 | | Joan López | GK |  | Independiente del Valle | Independiente |
| 01/2021 | | Jordan Estupiñan | GK | | Independiente del Valle | Independiente |
| 01/2021 | | Fernando Cagua | DF | | Deportivo Cuenca | Cuenca |
| 01/2021 | | Saul Castro | DF | | Independiente del Valle U20 | U20 |
| 01/2021 | | Johao Chávez | DF | | Deportivo Cuenca | Cuenca |
| 01/2021 | | Anderson Córtez | DF | |||
| 01/2021 | | Garis Mina | DF | | Independiente del Valle U20 | U20 |
| 01/2021 | | José Monaga | DF |  | El Nacional | El Nacional |
| 01/2021 | | Gino Angulo | MF | |||
| 01/2021 |  | Jimmy Ayovi | MF | |||
| 01/2021 | | Milton Cagua | MF | |||
| 01/2021 | | Carlos Gruezo | MF | |||
| 01/2021 | | Vicente Jaime | MF | | Independiente del Valle | Independiente |
| 01/2021 | | Fernando Guerrero | FW | | Independiente del Valle | Independiente |
| 01/2021 | | Stiven Plaza | FW |  | Real Valladolid | Valladolid |
| 01/2021 | | Renny Simisterra | FW | | Independiente del Valle | Independiente |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 | | Pedro Vite | FW |  | Vancouver Whitecaps | Vancouver |
| 01/2021 | | Kleber Pinargote | GK | | Independiente del Valle | Independiente |
| 01/2021 | | Lenín Usca | GK |  | 9 de Octubre | 9 de Octubre |
| 01/2021 | | Jhoanner Chávez | DF | | Independiente del Valle | Independiente |
| 01/2021 | | Luis Loor | DF |  | Liga de Portoviejo | LDU |
| 01/2021 | | Bryan García | MF | | Independiente del Valle | Independiente |
| 01/2021 | | José Hurtado | MF | | Independiente del Valle | Independiente |
| 01/2021 | | Andrés Mena | MF |  | Rangers | Rangers |
| 01/2021 | | Mateo Ortiz | MF | | Independiente del Valle | Independiente |
| 01/2021 | | Joffre Revelo | MF |  | Independiente del Valle U19 | U19 |