All-time best penalty takers
| # | Name | Matches | 11m | |
|---|---|---|---|---|
| 1 |  | Iván Alonso | 87 | 14 |
 | Nicolás López | 103 | 14 | |
| 3 |  | Gonzalo Bergessio | 174 | 12 |
| 4 |  | Maximiliano Gómez | 56 | 9 |
| 5 |  | Sebastián Fernández | 207 | 7 |
| 6 |  | Richard Porta | 55 | 6 |
 | Ignacio Ramírez | 76 | 6 | |
| 8 |  | Juan Mujica | 53 | 5 |
| 9 |  | Sebastián Abreu | 28 | 4 |
 | Gonzalo Carneiro | 67 | 4 | |
 | Santiago García | 81 | 4 | |
| 12 |  | Sergio Blanco | 34 | 3 |
 | Emmanuel Gigliotti | 67 | 3 | |
| 14 |  | Rubén Bentancourt | 42 | 2 |
 | Felipe Carballo | 178 | 2 | |
 | Christian Ebere | 29 | 2 | |
 | Leandro Fernández | 32 | 2 | |
 | Federico Martínez | 38 | 2 | |
 | Alexander Medina | 73 | 2 | |
 | Mario Méndez | 15 | 2 | |
 | Richard Morales | 44 | 2 | |
 | Diego Polenta | 230 | 2 | |
 | Federico Santander | 29 | 2 | |
 | Rubén Sosa | 27 | 2 | |
 | Thiago Vecino | 58 | 2 | |
| 26 |  | Rodrigo Aguirre | 33 | 1 |
 | Gabriel Álvez | 29 | 1 | |
 | Sebastián Balsas | 20 | 1 | |
 | Joaquín Boghossian | 18 | 1 | |
 | Matías Cabrera | 97 | 1 | |
 | Gonzalo Castro | 129 | 1 | |
 | Martín Cauteruccio | 13 | 1 | |
 | Tiziano Correa | 17 | 1 | |
 | Luis Cubilla | 44 | 1 | |
 | Federico Domínguez | 9 | 1 | |
 | Bruno Fornaroli | 21 | 1 | |
 | Marcelo Gallardo | 15 | 1 | |
 | Gianni Guigou | 32 | 1 | |
 | Pablo Islas | 7 | 1 | |
 | Léo Gamalho | 16 | 1 | |
 | Nicolás Lodeiro | 55 | 1 | |
 | Arsenio Luzardo | 34 | 1 | |
 | Sergio Martínez | 14 | 1 | |
 | Denis Milar | 9 | 1 | |
 | Manuel Monzeglio | 32 | 1 | |
 | Ángel Morales | 40 | 1 | |
 | Julio Morales | 78 | 1 | |
 | Gustavo Munúa | 86 | 1 | |
 | Juan Carlos Ocampo | 11 | 1 | |
 | Luis Ramos | 30 | 1 | |
 | Álvaro Recoba | 108 | 1 | |
 | Andrés Scotti | 81 | 1 | |
 | Carlos Soca | 27 | 1 | |
 | Gustavo Varela | 75 | 1 | |
 | Eduardo Vargas | 16 | 1 |