Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 11/2021 |  | Victor Álvarez | MF | |||
| 11/2021 | | Bryan Peña | MF | |||
| 08/2021 | | Paul Vélez | MA | |||
| 07/2021 | | Marco Montaño | DF |  | Olmedo | Olmedo |
| 07/2021 | | Marlon Ruiz | GK | |||
| 07/2021 | | Bryan Rodríguez | MF | | Olmedo | Olmedo |
| 07/2021 |  | Jorge Ortega | FW | |||
| 06/2021 |  | Fabricio Fernández | MF |  | Progreso | Progreso |
| 05/2021 | | Byron Vargas | GK | |||
| 03/2021 | | Freddy Mina | MF | |||
| 01/2021 |  | Matías Cortave | DF |  | Deportivo Morón | Morón |
| 01/2021 | | Blas Díaz | MF | |||
| 01/2021 | | Segundo Portocarrero | FW |  | Delfín SC | Delfín SC |
| 01/2021 | | Jorge Pucheta | GK |  | All Boys | All Boys |
| 01/2021 | | Bryan Hernández | DF |  | América de Quito | América |
| 01/2021 | | Richard Calderón | MF | | América de Quito | América |
| 01/2021 | | Matías Duffard | MF |  | Guayaquil City | Guayaquil |
| 01/2021 | | Iván Zambrano | MF |  | Técnico Universitario | Técnico |
| 01/2021 | | Muriel Orlando | FW |  | Mushuc Runa | Mushuc Runa |
| 01/2021 | | Brando Villacis | DF |  | Fuerza Amarilla | Fuerza Amarilla |
| 01/2021 | | Andy Burbano | DF | | Delfín SC | Delfín SC |
| 01/2021 | | Marcelo Jaramillo | DF | |||
| 01/2021 | | Jonathan Arroyo | MF | |||
| 01/2021 | | José Lugo | FW | | América de Quito | América |
| 01/2021 | | Roger Vera | FW | |||
| 01/2021 | | Eduardo Favaro | MA |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 | | Muriel Orlando | FW |  | Deportivo Cuenca | Cuenca |
| 07/2021 | | José Lugo | FW | | América de Quito | América |
| 01/2021 | | Galo Corozo | DF |  | Liga de Portoviejo | LDU |
| 01/2021 | | César Mercado | DF | | Liga de Portoviejo | LDU |
| 01/2021 | | Braian Molina | DF | | Deportivo Morón | Morón |
| 01/2021 | | Leonel Quiñónez | DF |  | Barcelona | Barcelona SC |
| 01/2021 | | Ángel Viotti | DF |  | Aucas | SD Aucas |
| 01/2021 | | Kener Arce | MF |  | Cumbayá | Cumbayá |
| 01/2021 | | Jonathan De la Cruz | MF | | América de Quito | América |
| 01/2021 | | Jhonathan Lucas | MF | | Técnico Universitario | Técnico |
| 01/2021 | | Mario Rizotto | MF | | Técnico Universitario | Técnico |
| 01/2021 | | Carlos Feraud | FW | | Mushuc Runa | Mushuc Runa |
| 01/2021 |  | Sebastián Herrera | FW |  | Deportivo Pasto | AD Pasto |
| 01/2021 | | Jonny Uchuari | FW |  | Orense SC | Orense |
| 01/2021 | | Paul Vélez | MA | | Delfín SC | Delfín SC |