Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 05.09.2021 |  | Matchday 1 | Águilas FC - Mancha Real | - MAN | 1:1 | |
| 19.09.2021 | | Matchday 3 | Águilas FC - Marchamalo | - | 2:0 | |
| 03.10.2021 | | Matchday 5 | Águilas FC - Intercity | - | 1:2 | |
| 17.10.2021 | | Matchday 7 | Águilas FC - UD Alzira | - | 2:2 | |
| 31.10.2021 | | Matchday 9 | Águilas FC - CA Pulpileño | - | 0:0 | |
| 14.11.2021 | | Matchday 11 | Águilas FC - El Ejido | - | 0:1 | |
| 27.11.2021 | | Matchday 13 | Águilas FC - Eldense | - | 0:1 | |
| 30.11.2021 |  | 1. Round | Águilas FC - Almería | - UDA | 3:5 | |
| 12.12.2021 | | Matchday 15 | Águilas FC - Murcia | - MUR | 1:2 |