Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 23.01.2022 |  | Matchday 15 | Chania - APS Zakynthos | CFC - APS | 5:1 | |
| 06.02.2022 | | Matchday 17 | Chania - Kallithea | CFC - Kal | 0:0 | |
| 09.02.2022 | | Matchday 12 | Chania - Asteras Vlachioti | CFC - | 3:1 | |
| 13.02.2022 | | Matchday 18 | Chania - AO Egaleo | CFC - | 1:0 | |
| 20.02.2022 | | Matchday 20 | Chania - Levadiakos | CFC - Lev | 3:1 | |
| 06.03.2022 | | Matchday 22 | Chania - AO Episkopi | CFC - | 1:0 | |
| 12.03.2022 | | Matchday 24 | Chania - AEK Athen II | CFC - | 2:1 | |
| 26.03.2022 | | Matchday 26 | Chania - Panathinaikos II | CFC - | 2:0 | |
| 03.04.2022 | | Matchday 28 | Chania - Ergotelis | CFC - Erg | 0:0 | |
| 10.04.2022 | | Matchday 30 | Chania - Diagoras FC | CFC - DFC | 2:0 | |
| 27.04.2022 | | Matchday 33 | Chania - OFI Ierapetra | CFC - | 2:0 |