Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 20.02.2022 |  | Matchday 21 | FK Senica - ŠKF Sereď | SEN - SER | 1:2 | 412 |
| 12.03.2022 | | Matchday 2 | FK Senica - MFK Zemplín | SEN - ZEM | 2:1 | 273 |
| 09.04.2022 | | Matchday 5 | FK Senica - FK Pohronie | SEN - | 2:1 | 283 |
| 16.04.2022 | | Matchday 6 | FK Senica - MFK Tatran | SEN - TAT | 0:3 | 313 |
| 20.04.2022 |  | Semi-finals 2nd leg | FK Senica - Spartak Trnava | SEN - TRN | 0:4 | |
| 30.04.2022 | | Matchday 8 | FK Senica - Zlaté Moravce | SEN - ZLM | 0:0 | 328 |
| 14.05.2022 | | Matchday 9 | FK Senica - AS Trenčín | SEN - AST | 0:3 | 323 |