Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 28.05.2022 |  | Matchday 5 | Atlético Santo Domingo - Guayaquil City | - | 0:1 | |
| 28.05.2022 |  | Matchday 5 | Atlético Santo Domingo - Guayaquil City | - | 0:0 | |
| 04.06.2022 | | Matchday 6 | Atlético Santo Domingo - Manta FC | - | 1:4 | |
| 04.06.2022 | | Matchday 6 | Atlético Santo Domingo - Manta FC | - | 3:1 | |
| 10.07.2022 | | Matchday 7 | Atlético Santo Domingo - 9 de Octubre | - | 2:1 | |
| 10.07.2022 | | Matchday 7 | Atlético Santo Domingo - 9 de Octubre | - | 3:0 | |
| 30.07.2022 | | Matchday 9 | Atlético Santo Domingo - Emelec | - | 1:4 | |
| 30.07.2022 | | Matchday 9 | Atlético Santo Domingo - Emelec | - | 1:2 |