Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Ben Cross | AS-CO |  | Columbus Crew | Columbus Crew |
| 12/2021 |  | Miguel Villagrasa | PH-C |  | Elche CF | Elche CF |
| 12/2021 | | Nico Estévez | MA | |||
| 09/2021 | | Marco Ferruzzi | MA | |||
| 07/2021 |  | Caiser Gomes | DF |  | North Texas SC | North Texas |
| 07/2021 | | Brandon Servania | MF |  | SKN St. Pölten | SKN St. Pölten |
| 07/2021 | | Javi Cabello | AS-CO |  | CD Alavés | Alavés |
| 06/2021 |  | Facundo Quignón | MF |  | Lanús | Lanús |
| 06/2021 | | Justin Che | DF |  | Bayern München II | Bayern II |
| 05/2021 | | Colin Shutler | GK | | North Texas SC | North Texas |
| 05/2021 |  | Szabolcs Schön | FW |  | MTK Budapest | MTK Budapest |
| 04/2021 | | Collin Smith | FW | |||
| 01/2021 | | Nicky Hernandez | MF | | North Texas SC | North Texas |
| 01/2021 |  | Thibaut Jacquel | FW |  | Campbell Fighting Camels | Campbell Fighting Camels |
| 01/2021 |  | Freddy Vargas | MF |  | Deportivo Lara | CD Lara |
| 01/2021 | | Kalil ElMedkhar | MF |  | Kentucky Wildcats | Kentucky Wildcats |
| 01/2021 | | José Martínez | DF |  | SD Eibar | Eibar |
| 01/2021 |  | Cristian Colmán | FW |  | Barcelona | Barcelona SC |
| 01/2021 |  | Jáder Obrian | FW |  | Águilas Doradas | Águilas |
| 01/2021 | | Beni Redžić | FW | | North Texas SC | North Texas |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 |  | Dante Sealy | FW |  | Jong PSV | Jong PSV |
| 07/2021 | | Tanner Tessmann | MF |  | Venezia FC | Venezia FC |
| 07/2021 | | Thomas Roberts | MF |  | SK Austria Klagenfurt | A. Klagenfurt |
| 05/2021 | | Collin Smith | FW | | North Texas SC | North Texas |
| 04/2021 |  | Thiago Santos | MF |  | Grêmio Porto Alegre | Grêmio |
| 03/2021 | | Thibaut Jacquel | FW | | North Texas SC | North Texas |
| 02/2021 | | Cristian Colmán | FW |  | Godoy Cruz | Godoy Cruz |
| 02/2021 |  | Carlos Ávilez | GK |  | Tormenta FC | Tormenta |
| 02/2021 | | Brandon Servania | MF | | SKN St. Pölten | SKN St. Pölten |
| 02/2021 | | Justin Che | DF |  | Bayern Munich U19 | Bayern Munich U19 |
| 02/2021 | | Bryan Reynolds | DF |  | AS Roma | AS Roma |
| 01/2021 | | Michael Barrios | MF |  | Colorado Rapids | Colorado Rapids |
| 01/2021 | | Harold Mosquera | FW |  | CF Pachuca | Pachuca |