Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 |  | Gustavo Dionisi | GK |  | Guaraní | Club Guaraní |
| 01/2022 | | Alcides Benítez | DF | |||
| 01/2022 | | Alexis Cantero | DF | | Guaraní | Club Guaraní |
| 01/2022 | | César Ramírez | DF | | Guaraní | Club Guaraní |
| 01/2022 | | René Rodriguez | DF | | Guaraní | Club Guaraní |
| 01/2022 | | Fernando Castro | MF | | Guaraní | Club Guaraní |
| 01/2022 | | Nelson Gauto | MF | | Guaraní | Club Guaraní |
| 01/2022 | | Tomás Giménez | MF | |||
| 01/2022 | | Lázaro González | MF | |||
| 01/2022 | | Mario Gonzalez | MF | | Guaraní | Club Guaraní |
| 01/2022 | | Andres Jara | MF | | Guaraní | Club Guaraní |
| 01/2022 | | Gustavo Medina | MF | |||
| 01/2022 | | Lucas Pereira | MF | |||
| 01/2022 | | Matías Segovia | MF | | Guaraní | Club Guaraní |
| 01/2022 | | Milciades Adorno | FW | |||
| 01/2022 | | Cristhian Báez | FW | |||
| 01/2022 | | Anderson Cino | FW | |||
| 01/2022 | | Oscar Echeverria | FW | |||
| 01/2022 | | Kevin Lezcano | FW | |||
| 01/2022 | | Víctor Rivarola | FW | |||
| 01/2022 | | Leonardo Rolón | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 | | Adrián Brizuela | DF |  | Tacuary | Tacuary |
| 07/2022 | | Anderson Cino | FW |  | Potros del Este | Potros |
| 07/2022 | | Leonardo Rolón | FW |  | General Caballero JLM | Caballero |
| 01/2022 | | Alcides Barbotte | DF | | Guaraní | Club Guaraní |
| 01/2022 | | Brahian Fernández | MF | | Guaraní | Club Guaraní |