Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 |  | Javier Domínguez | MF |  | Sportivo Luqueño | Luqueño |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2022 | | Diego Morel | GK |  | 2 de Mayo | 2 de Mayo |
| 03/2022 | | Lorenzo Frutos | FW |  | Boca Unidos | Boca Unidos |
| 01/2022 | | Silvio Torales | MF |  | Real Santa Cruz | Santa Cruz |