Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 06/2022 |  | Joao Rojas | FW |  | Emelec | Emelec |
| 03/2022 |  | Juan Machado | FW |  | CF Monterrey II | CF Monterrey II |
| 03/2022 | | Víctor Vucetich | MA | |||
| 03/2022 | | Sergio Almaguer | AS-CO | |||
| 03/2022 | | Carlos Barra | AS-CO | |||
| 01/2022 | | William Mejía | MF | | CF Monterrey II | CF Monterrey II |
| 01/2022 | | Luis Romo | MF |  | Cruz Azul | Cruz Azul |
| 01/2022 | | Rodolfo Pizarro | MF |  | Inter Miami CF | Inter Miami |
| 09/2021 |  | Jacobo Reyes | FW | | CF Monterrey II | CF Monterrey II |
| 07/2021 |  | Esteban Andrada | GK |  | Boca Juniors | Boca Juniors |
| 07/2021 | | César Ramos | GK |  | CF Monterrey U20 | U20 |
| 07/2021 | | Alán Montes | DF |  | Club Necaxa U20 | U20 |
| 07/2021 | | Héctor Moreno | DF |  | Al Gharafa | Al Gharafa |
| 07/2021 | | Sergio Villarreal | DF | | CF Monterrey U20 | U20 |
| 07/2021 | | Érick Aguirre | MF |  | CF Pachuca | Pachuca |
| 07/2021 |  | Daniel Lajud | MF |  | TM Fútbol Club | Tampico Madero |
| 07/2021 | | Jaziel Martínez | MF | | CF Monterrey U20 | U20 |
| 07/2021 | | Michell Rodríguez | MF |  | Cancún FC | Cancún |
| 07/2021 | | Ángel Zapata | MF | | CF Monterrey U20 | U20 |
| 07/2021 |  | Joel Campbell | FW |  | Club León | Club León |
| 07/2021 |  | Duván Vergara | FW |  | América de Cali | América |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 | | Edson Reséndez | GK | | Cancún FC | Cancún |
| 01/2022 | | Carlos Rodríguez | MF | | Cruz Azul | Cruz Azul |
| 07/2021 | | Dorlan Pabón | FW |  | Atlético Nacional | Atl. Nacional |
| 07/2021 | | Hugo González | GK |  | FC Juárez | FC Juárez |
| 07/2021 | | Miguel Layún | DF |  | CF América | CF América |
| 07/2021 | | Adrián Mora | DF | | FC Juárez | FC Juárez |
| 07/2021 | | Nicolás Sánchez | DF |  | Godoy Cruz | Godoy Cruz |
| 07/2021 | | Juan Álvarez | MF | | CF Monterrey II | CF Monterrey II |
| 07/2021 | | Eric Cantú | MF |  | Atlético San Luis | San Luis |
| 07/2021 | | Jonathan González | MF |  | Club Necaxa | Necaxa |
| 07/2021 | | Neder Hernández | MF | | CF Monterrey II | CF Monterrey II |
| 07/2021 | | Ali Ávila | FW | | CF Monterrey II | CF Monterrey II |
| 07/2021 | | Avilés Hurtado | FW | | CF Pachuca | Pachuca |