Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 |  | Pablo Galindo | DF | |||
| 07/2021 |  | Pablo Godoy | MA | |||
| 07/2021 |  | Orlando Mosquera | GK |  | Boluspor | Boluspor |
| 07/2021 | | Sebastián Claure | MF | |||
| 07/2021 | | Luis Rivas | MF | |||
| 07/2021 | | Jair Catuy | FW |  | UD Universitario | Universitario |
| 04/2021 |  | Omar Asad | MA | |||
| 04/2021 |  | Alex Rambal | DF | |||
| 03/2021 | | Hárold Cummings | DF |  | Unión Española | Unión Española |
| 03/2021 | | Jorge Flores | DF |  | Bolívar | Bolívar |
| 03/2021 | | Diego Medina | DF | |||
| 03/2021 | | Juan Carlos Arce | FW | | Bolívar | Bolívar |
| 02/2021 |  | Mascote | FW |  | Lemense EC - SP | Lemense |
| 02/2021 | | Júnior Viçosa | FW |  | Vitória - BA | EC Vitória |
| 01/2021 | | Santiago Arce | MF |  | Club Aurora | Club Aurora |
| 01/2021 | | Carmelo Algarañaz | FW |  | Oriente Petrolero | Petrolero |
| 01/2021 |  | Sebastián Núñez | MA | |||
| 01/2021 | | Rubén Cordano | GK |  | Blooming | Blooming |
| 01/2021 | | Pablo Vaca | DF | |||
| 01/2021 |  | Robert Hernández | MF |  | Caracas FC | Caracas FC |
| 01/2021 | | Cristhian Machado | MF | | Bolívar | Bolívar |
| 01/2021 | | Javier Uzeda | MF | |||
| 01/2021 | | José Martínez | FW | |||
| 01/2021 | | Vander | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Vander | FW |  | Sport Recife - PE | SC Recife |
| 08/2021 | | Mascote | FW | | Lemense EC - SP | Lemense |
| 07/2021 | | Carlos Puña | MF |  | Real Tomayapo | Tomayapo |
| 07/2021 | | John Mosquera | FW |  | CD Guabirá | CD Guabirá |
| 04/2021 | | Víctor Melgar | MF |  | Independiente Petrolero | Independiente |
| 04/2021 | | Júnior Viçosa | FW |  | Brasil de Pelotas - RS | Brasil |
| 02/2021 | | Rubén Cordano | GK | | Bolívar | Bolívar |
| 01/2021 | | Marcos Barrera | DF |  | Huracán de Las Heras | Huracán |
| 01/2021 | | Anderson Rey | DF |  | Gimnasia de Jujuy | GyE Jujuy |
| 01/2021 | | Jair Torrico | DF |  | Royal Pari | Royal Pari |
| 01/2021 | | Marcelo Gallardo | MF | | Real Tomayapo | Tomayapo |
| 01/2021 | | Rafael Silva | MF |  | Al Shorta | Al Shorta |
| 01/2021 | | Gustavo Britos | FW |  | CSD Municipal | Municipal |
| 01/2021 | | Milton Garzón | FW | | Real Tomayapo | Tomayapo |
| 01/2021 | | Jimmy Isita | FW | | Real Tomayapo | Tomayapo |
| 01/2021 | | Jorge Rojas | FW | | Blooming | Blooming |
| 01/2021 | | Leonel López | DF | | Real Tomayapo | Tomayapo |
| 01/2021 | | José Orellana | DF | | Bolívar | Bolívar |