Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 05/2022 |  | Umut Tohumcu | MF |  | TSG Hoffenheim II | Hoffenheim II |
| 05/2022 | | Nick Proschwitz | FW | | TSG Hoffenheim II | Hoffenheim II |
| 02/2022 | | Bambasé Conté | MF | | TSG Hoffenheim II | Hoffenheim II |
| 01/2022 |  | Justin Che | DF |  | FC Dallas | FC Dallas |
| 01/2022 | | Tom Bischof | MF | | TSG Hoffenheim II | Hoffenheim II |
| 01/2022 | | Martin Seiler | AT-C |  | TSG Hoffenheim U19 | Hoffenheim U19 |
| 01/2022 |  | Lucas Ribeiro | DF |  | Internacional | Internacional |
| 01/2022 | | Niklas Hagenhoff | G-AN | |||
| 11/2021 |  | Fisnik Asllani | FW | | TSG Hoffenheim II | Hoffenheim II |
| 08/2021 | | Chris Richards | DF |  | Bayern Munich | Bayern Munich |
| 08/2021 | | Noah König | DF | | TSG Hoffenheim II | Hoffenheim II |
| 08/2021 | | Fabian Rüth | DF | | TSG Hoffenheim II | Hoffenheim II |
| 07/2021 |  | Justin Hoogma | DF |  | FC Utrecht | FC Utrecht |
| 07/2021 | | David Raum | DF |  | SpVgg Greuther Fürth | Gr. Fürth |
| 07/2021 | | Angelo Stiller | MF | | Bayern Munich | Bayern Munich |
| 07/2021 |  | Jacob Bruun Larsen | FW |  | RSC Anderlecht | Anderlecht |
| 07/2021 | | Hans-Dieter Hermann | MEN-C |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 |  | Joshua Brenet | DF |  | FC Twente | FC Twente |
| 01/2022 |  | Mijat Gaćinović | MF |  | Panathinaikos A.O. | Panathinaikos |
| 01/2022 |  | Sargis Adamyan | FW |  | Club Brugge KV | Brugge KV |
| 01/2022 | | Lucas Ribeiro | DF |  | Ceará - CE | Ceará SC |
| 01/2022 | | Melayro Bogarde | DF |  | FC Groningen | Groningen |
| 01/2022 | | Fabian Rüth | DF |  | Rot-Weiss Essen | RW Essen |
| 01/2022 | | Yannic Hess | G-AN |  | FC Basel 1893 | FC Basel |
| 08/2021 |  | Ishak Belfodil | FW |  | Hertha BSC | Hertha BSC |
| 08/2021 | | Maximilian Beier | FW |  | Hannover 96 | Hannover |
| 08/2021 |  | Kostas Stafylidis | DF |  | VfL Bochum | Bochum |
| 07/2021 | | Justin Hoogma | DF | | SpVgg Greuther Fürth | Gr. Fürth |
| 07/2021 | | Max Geschwill | DF | | TSG Hoffenheim II | Hoffenheim II |
| 07/2021 | | Chris Richards | DF | | Bayern Munich | Bayern Munich |
| 07/2021 |  | Ryan Sessegnon | FW |  | Tottenham Hotspur | Tottenham |