Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 |  | Roberto Ordóñez | FW |  | Aucas | SD Aucas |
| 07/2021 | | Galo Corozo | DF |  | Liga de Portoviejo | LDU |
| 07/2021 | | Joel Quintero | DF |  | Olmedo | Olmedo |
| 07/2021 | | Jordan Rezabala | MF | | Olmedo | Olmedo |
| 07/2021 |  | Alejandro Frezzotti | MF |  | Mitre de SdE | CA Mitre |
| 04/2021 | | Roddy Salazar | DF | |||
| 03/2021 | | Luis Caicedo | DF |  | Delfín SC | Delfín SC |
| 03/2021 |  | Federico Cristóforo | GK |  | Villa Teresa | Villa Teresa |
| 02/2021 |  | Julio Domínguez | DF |  | Danubio | Danubio |
| 02/2021 | | Nicolás Prieto | MF | | Danubio | Danubio |
| 01/2021 | | José Flor | DF | |||
| 01/2021 | | José Angulo | FW |  | Club Tijuana | Club Tijuana |
| 01/2021 | | Vinicio Angulo | FW | | Liga de Portoviejo | LDU |
| 01/2021 | | Hamilton Piedra | GK |  | Independiente del Valle | Independiente |
| 01/2021 | | Beder Valencia | GK |  | Técnico Universitario | Técnico |
| 01/2021 | | Jordán Jaime | DF | |||
| 01/2021 | | Jonathan Caicedo | MF |  | 9 de Octubre | 9 de Octubre |
| 01/2021 | | Maikol Castro | MF | |||
| 01/2021 | | Jonathan Majao | MF |  | Manta FC U19 | U19 |
| 01/2021 | | Gerardo Martínez | MF |  | Universidad Técnica | UT Cajamarca |
| 01/2021 | | Hansell Portocarrero | MF | | Manta FC U19 | U19 |
| 01/2021 | | Martín Alaníz | FW |  | Orense SC | Orense |
| 01/2021 | | Marcos Romero | FW | | Olmedo | Olmedo |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 07/2021 | | José Angulo | FW | | Independiente del Valle | Independiente |
| 07/2021 | | Federico Cristóforo | GK |  | River Plate | Ríver Plate |
| 01/2021 | | Luis Caicedo | DF | | Delfín SC | Delfín SC |
| 01/2021 | | Jimmy Gómez | DF | | Liga de Portoviejo | LDU |
| 01/2021 | | Alejandro Prieto | DF |  | Atlético Porteño | Atlético Porteño |
| 01/2021 | | Jordan Cedeño | MF | | Liga de Portoviejo | LDU |
| 01/2021 | | Luis Dominguez | MF | | Delfín SC | Delfín SC |
| 01/2021 | | Cristian Garcia | MF |  | Atlanta | Atlanta |
| 01/2021 | | Klever Vélez | MF | | Liga de Portoviejo | LDU |
| 01/2021 | | Mario Barrionuevo | FW |  | Gualaceo SC | Gualaceo SC |
| 01/2021 | | Christian Márquez | FW | | Gualaceo SC | Gualaceo SC |