Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 |  | Luis Cartés | GK |  | Rampla Juniors | Rampla Juniors |
| 09/2021 | | Andrés García | FW |  | CA Cerro | CA Cerro |
| 08/2021 | | Sebastián Cardozo | DF |  | Cerrito | Cerrito |
| 08/2021 | | Mario Zipitría | DF | |||
| 08/2021 | | Diego Martiñones | FW | | Rampla Juniors | Rampla Juniors |
| 07/2021 | | Iván Salazar | MF |  | Plaza Colonia | Plaza Colonia |
| 07/2021 | | Enzo Castillo | DF |  | Villa Española | Española |
| 07/2021 | | Óscar Castro | DF | | Rampla Juniors | Rampla Juniors |
| 07/2021 | | Nicolás Da Fonte | DF | | Villa Española | Española |
| 07/2021 | | Lucas De Los Santos | DF | | Cerrito | Cerrito |
| 07/2021 | | Néstor del Río | DF | |||
| 07/2021 | | Máximo Lorenzi | DF | |||
| 07/2021 | | Sebastián Burgos | MF | |||
| 07/2021 | | Richard Caetano | MF | | Cerrito | Cerrito |
| 07/2021 | | Guillermo Méndez | MF | |||
| 07/2021 | | Rodrigo Viera | MF | |||
| 07/2021 | | Carlos Sánchez | FW | |||
| 07/2021 | | Julio Fuentes | MA | |||
| 04/2021 | | Bruno Ávila | FW | | Cerrito | Cerrito |
| 03/2021 | | Facundo Pérez | MF |  | Central Español | Español |
| 02/2021 | | John Faust | GK | | Rampla Juniors | Rampla Juniors |
| 01/2021 | | Jonathan Píriz | DF | | Central Español | Español |
| 01/2021 | | Emanuel Fuentes | MF | | Villa Española | Española |
| 01/2021 | | Fernando Olivera | MF | | Central Español | Español |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2021 | | Carlos Santucho | DF | | Villa Española | Española |