| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 01.07.2021 | Matchday 5 | Matchday 5 | A | ![]() | Villa Teresa | D | 2:20:1 |
| 08.07.2021 | Matchday 6 | Matchday 6 | H | ![]() | Juventud | W | 2:12:1 |
| 14.07.2021 | Matchday 7 | Matchday 7 | A | ![]() | Uru Montevideo | L | 1:20:1 |
| 23.07.2021 | Matchday 8 | Matchday 8 | H | ![]() | Rampla Juniors | W | 2:01:0 |
| 29.07.2021 | Matchday 9 | Matchday 9 | A | ![]() | Danubio | L | 0:10:1 |
| 04.08.2021 | Matchday 10 | Matchday 10 | H | ![]() | Albion | L | 0:20:1 |
| 12.08.2021 | Matchday 11 | Matchday 11 | H | ![]() | CA Cerro | L | 1:30:1 |
| 16.09.2021 | Matchday 12 | Matchday 12 | H | ![]() | Defensor | L | 1:20:0 |
| 22.09.2021 | Matchday 13 | Matchday 13 | A | ![]() | Español | L | 0:10:1 |
| 30.09.2021 | Matchday 14 | Matchday 14 | H | ![]() | Atenas | L | 0:10:0 |
| 06.10.2021 | Matchday 15 | Matchday 15 | A | ![]() | Racing | L | 0:30:1 |
| 14.10.2021 | Matchday 16 | Matchday 16 | H | ![]() | Villa Teresa | D | 1:11:0 |
| 19.10.2021 | Matchday 17 | Matchday 17 | A | ![]() | Juventud | L | 0:10:0 |
| 27.10.2021 | Matchday 18 | Matchday 18 | H | ![]() | Uru Montevideo | L | 1:20:1 |
| 01.11.2021 | Matchday 19 | Matchday 19 | A | ![]() | Rampla Juniors | L | 1:20:2 |
| 10.11.2021 | Matchday 20 | Matchday 20 | H | ![]() | Danubio | L | 1:21:0 |
| 18.11.2021 | Matchday 21 | Matchday 21 | A | ![]() | Albion | W | 1:01:0 |
| 24.11.2021 | Matchday 22 | Matchday 22 | A | ![]() | CA Cerro | L | 0:30:1 |
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