Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 |  | Santiago Amorín | GK |  | Villa Española | Española |
| 09/2021 | | Luis Rodríguez | FW |  | Cerro Largo | Cerro Largo |
| 04/2021 | | Cristian Cruz | MF |  | Fénix | Fénix |
| 04/2021 | | Sergio Núñez | FW |  | Peñarol | Peñarol |
| 04/2021 | | Federico Rodríguez | FW |  | Deportivo Maldonado | Maldonado |
| 04/2021 |  | Maximiliano Pérez | FW |  | Montevideo Wanderers | Wanderers |
| 04/2021 | | Nicolás Gentilio | GK | |||
| 04/2021 | | Kevin Larrea | GK | |||
| 04/2021 | | Maximiliano Amondarain | DF |  | Rentistas | Rentistas |
| 04/2021 | | Diego Rodríguez | DF | |||
| 04/2021 | | Matías Malvino | DF | |||
| 04/2021 | | Ignacio Avilés | MF |  | San Marcos | San Marcos |
| 04/2021 | | Gonzalo Da Luz | MF | |||
| 04/2021 | | Lucas Ribeiro | FW | |||
| 04/2021 | | Maximiliano Calzada | MF |  | River Plate | River Plate |
| 04/2021 | | Owen Falconis | FW | |||
| 03/2021 | | Fernando López | MF | |||
| 03/2021 | | Alejandro Villoldo | DF | |||
| 03/2021 | | Damián González | MF | |||
| 02/2021 | | Flavio Scarone | FW |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Fabián Vargas | DF |  | Progreso | Progreso |
| 08/2021 | | Sebastián Cardozo | DF |  | La Luz | La Luz |
| 07/2021 | | Lucas De Los Santos | DF | | La Luz | La Luz |
| 07/2021 | | Richard Caetano | MF | | La Luz | La Luz |
| 04/2021 | | Nicolás Marticorena | GK |  | Villa Teresa | Villa Teresa |
| 04/2021 | | Bruno Ávila | FW | | La Luz | La Luz |
| 04/2021 | | Raúl Tarragona | FW |  | Central Español | Español |
| 02/2021 | | Rodrigo Pérez | MF |  | Atenas | Atenas |
| 01/2021 | | Maximiliano Viera | FW |  | 9 de Octubre | 9 de Octubre |
| 01/2021 | | Juan Martin Gonella | FW |  | Mineros de Guayana | Mineros |