| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 20.08.2005 | Matchday 1 | Matchday 1 | H | ![]() | Defensor | W | 2:1 |
| 28.08.2005 | Matchday 2 | Matchday 2 | A | ![]() | Tacuarembó | D | 1:1 |
| 11.09.2005 | Matchday 3 | Matchday 3 | A | ![]() | Danubio | L | 0:2 |
| 17.09.2005 | Matchday 4 | Matchday 4 | H | ![]() | River Plate | D | 0:0 |
| 22.09.2005 | Matchday 5 | Matchday 5 | H | ![]() | Nacional | D | 1:1 |
| 24.09.2005 | Matchday 6 | Matchday 6 | A | ![]() | Wanderers | L | 2:3 |
| 02.10.2005 | Matchday 7 | Matchday 7 | H | ![]() | Plaza Colonia | L | 0:1 |
| 16.10.2005 | Matchday 8 | Matchday 8 | A | ![]() | Fénix | W | 1:0 |
| 22.10.2005 | Matchday 9 | Matchday 9 | H | ![]() | Rampla Juniors | W | 3:2 |
| 29.10.2005 | Matchday 10 | Matchday 10 | A | ![]() | Rocha | L | 0:2 |
| 02.11.2005 | Matchday 11 | Matchday 11 | H | ![]() | Misiones | D | 1:1 |
| 05.11.2005 | Matchday 12 | Matchday 12 | A | ![]() | Rentistas | W | 3:1 |
| 19.11.2005 | Matchday 13 | Matchday 13 | H | ![]() | Colonia | D | 1:1 |
| 27.11.2005 | Matchday 14 | Matchday 14 | A | ![]() | CA Cerro | D | 1:1 |
| 03.12.2005 | Matchday 15 | Matchday 15 | A | ![]() | Peñarol | D | 0:0 |
| 07.12.2005 | Matchday 16 | Matchday 16 | H | ![]() | Paysandú FC | W | 3:1 |
| 11.12.2005 | Matchday 17 | Matchday 17 | A | ![]() | Liverpool FC | W | 1:0 |
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