Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 10/2021 |  | Michael Mieles | MF | |||
| 10/2021 | | Cristhian García | DF | |||
| 08/2021 |  | Horacio Montemurro | MA | |||
| 07/2021 | | Jefferson Huerta | MA | |||
| 07/2021 | | Gabriel Corozo | DF |  | Olmedo | Olmedo |
| 07/2021 | | Gonzalo Ritacco | MF | |||
| 07/2021 | | Tito Vicuña | MF |  | Universitario de Portoviejo | Universitario |
| 03/2021 | | Maikel Reyes | MF | |||
| 03/2021 | | Joaquín Susvielles | FW |  | Platense | Platense |
| 02/2021 |  | Jefre Vargas | DF | |||
| 01/2021 | | Cristian García | MF |  | Guillermo Brown | Brown |
| 01/2021 | | Kevin Peralta | DF |  | El Nacional | El Nacional |
| 01/2021 | | Juan Vieyra | MF |  | Central Córdoba SdE | Central Córdoba |
| 01/2021 | | Robert Burbano | MF |  | Emelec | Emelec |
| 01/2021 | | Luis Estupiñán | MF | |||
| 01/2021 | | José Hernández | MF | |||
| 01/2021 | | Bryan De Jesús | FW |  | Universidad Católica | Uni. Católica |
| 01/2021 | | Oscar Piris | DF |  | Montevideo City Torque | Torque |
| 01/2021 | | Matías Pérez | DF |  | Tigre | C. A. T. |
| 01/2021 | | Luis Becerra | DF | |||
| 01/2021 | | Luis Caicedo | DF |  | Manta | Manta |
| 01/2021 | | Wilmar Meneses | DF |  | Deportivo Cuenca | Cuenca |
| 01/2021 | | Joffre Monrroy | DF |  | Santa Rita | Santa Rita |
| 01/2021 | | Luis Dominguez | MF | | Manta | Manta |
| 01/2021 | | Jostin Alman | FW |  | Orense SC | Orense |
| 01/2021 | | Paul Vélez | MA |  | Macará | Macará |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 09/2021 | | Juan Vieyra | MF |  | Cobresal | CD Cobresal |
| 08/2021 |  | José Valencia | FW |  | Deportivo Pereira | Pereira |
| 07/2021 | | Jefre Vargas | DF |  | Metropolitanos FC | Metropolitanos FC |
| 07/2021 | | Luis Estupiñán | MF |  | Técnico Universitario | Técnico |
| 03/2021 | | Bryan De Jesús | FW | | Olmedo | Olmedo |
| 03/2021 | | Luis Caicedo | DF | | Manta | Manta |
| 02/2021 | | Óscar Benítez | MF |  | Atlético Tucumán | Atlético Tucumá |
| 02/2021 | | Matías Pérez | DF |  | Estudiantes de Caseros | Estudiantes |
| 01/2021 | | Jerry León | DF | | Olmedo | Olmedo |
| 01/2021 | | Geovanny Nazareno | DF | | Deportivo Cuenca | Cuenca |
| 01/2021 | | Harold Gonzalez | DF |  | Aucas | SD Aucas |
| 01/2021 | | Segundo Portocarrero | DF | | Macará | Macará |
| 01/2021 |  | Agustín Ale | DF |  | River Plate | River Plate |
| 01/2021 | | Andy Burbano | DF | | Macará | Macará |
| 01/2021 | | Tommy Mina | DF |  | Búhos ULVR | Búhos |
| 01/2021 | | Carlos Rodríguez | DF |  | LDU Quito | LDU Quito |
| 01/2021 | | Julián Guevara | MF |  | Unión Comercio | Unión Comercio |
| 01/2021 |  | Niko Kata | MF |  | Real Estelí FC | Real Estelí FC |
| 01/2021 | | David Noboa | MF |  | Guayaquil City | Guayaquil |
| 01/2021 | | Carlos Garcés | FW |  | Barcelona | Barcelona SC |