| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 23.01.2010 | Matchday 1 | Matchday 1 | A | ![]() | Nacional | L | 1:31:2 |
| 30.01.2010 | Matchday 2 | Matchday 2 | A | ![]() | Cerrito | D | 1:11:0 |
| 06.02.2010 | Matchday 3 | Matchday 3 | A | ![]() | Español | W | 2:11:0 |
| 13.02.2010 | Matchday 4 | Matchday 4 | H | ![]() | Fénix | W | 1:00:0 |
| 20.02.2010 | Matchday 5 | Matchday 5 | A | ![]() | Danubio | L | 0:20:1 |
| 27.02.2010 | Matchday 6 | Matchday 6 | H | ![]() | Atenas | L | 0:20:1 |
| 07.03.2010 | Matchday 7 | Matchday 7 | A | ![]() | Peñarol | L | 0:50:2 |
| 13.03.2010 | Matchday 8 | Matchday 8 | H | ![]() | Defensor | L | 1:30:0 |
| 27.03.2010 | Matchday 10 | Matchday 10 | H | ![]() | Rampla Juniors | D | 1:10:0 |
| 31.03.2010 | Matchday 9 | Matchday 9 | A | ![]() | Racing | W | 2:11:1 |
| 04.04.2010 | Matchday 11 | Matchday 11 | A | ![]() | Wanderers | L | 1:70:2 |
| 10.04.2010 | Matchday 12 | Matchday 12 | H | ![]() | River Plate | D | 2:21:1 |
| 18.04.2010 | Matchday 13 | Matchday 13 | H | ![]() | CA Cerro | L | 0:10:0 |
| 25.04.2010 | Matchday 14 | Matchday 14 | A | ![]() | Liverpool FC | L | 0:30:2 |
| 02.05.2010 | Matchday 15 | Matchday 15 | H | ![]() | Tacuarembó | L | 1:21:0 |
Cerro Largo















