| Date | Round | Round | H/A | Res. | |||
|---|---|---|---|---|---|---|---|
| 21.08.2005 | Matchday 1 | Matchday 1 | H | ![]() | Misiones | L | 0:3 |
| 27.08.2005 | Matchday 2 | Matchday 2 | H | ![]() | Peñarol | L | 0:1 |
| 11.09.2005 | Matchday 3 | Matchday 3 | H | ![]() | Colonia | D | 1:1 |
| 17.09.2005 | Matchday 4 | Matchday 4 | A | ![]() | Cerrito | D | 0:0 |
| 21.09.2005 | Matchday 5 | Matchday 5 | A | ![]() | Rentistas | W | 2:1 |
| 25.09.2005 | Matchday 6 | Matchday 6 | A | ![]() | Tacuarembó | W | 3:0 |
| 01.10.2005 | Matchday 7 | Matchday 7 | H | ![]() | Rocha | W | 2:1 |
| 15.10.2005 | Matchday 8 | Matchday 8 | A | ![]() | CA Cerro | D | 1:1 |
| 22.10.2005 | Matchday 9 | Matchday 9 | A | ![]() | Nacional | D | 0:0 |
| 30.10.2005 | Matchday 10 | Matchday 10 | A | ![]() | Rampla Juniors | W | 4:1 |
| 02.11.2005 | Matchday 11 | Matchday 11 | H | ![]() | Wanderers | D | 0:0 |
| 06.11.2005 | Matchday 12 | Matchday 12 | H | ![]() | Fénix | W | 4:2 |
| 19.11.2005 | Matchday 13 | Matchday 13 | H | ![]() | Danubio | L | 0:3 |
| 27.11.2005 | Matchday 14 | Matchday 14 | A | ![]() | Paysandú FC | W | 3:2 |
| 04.12.2005 | Matchday 15 | Matchday 15 | A | ![]() | Liverpool FC | L | 1:2 |
| 07.12.2005 | Matchday 16 | Matchday 16 | H | ![]() | Plaza Colonia | L | 1:2 |
| 11.12.2005 | Matchday 17 | Matchday 17 | H | ![]() | Defensor | D | 2:2 |
River Plate

















