Additions
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 03/2022 |  | Alejandro Asensio | FW | |||
| 03/2022 | | Adrián Moya | GK |  | Rayo Vallecano B | Rayo B |
| 01/2022 |  | Mamadou Sylla | FW |  | CD Alavés | Alavés |
| 12/2021 | | Álvaro Aguirre | FW | |||
| 09/2021 |  | Iván Arboleda | GK | |||
| 09/2021 | | Radamel Falcao | FW |  | Galatasaray | Galatasaray |
| 08/2021 |  | Nikola Maraš | DF |  | UD Almería | Almería |
| 08/2021 | | Unai López | MF |  | Athletic Club | Athletic |
| 08/2021 | | Sergi Guardiola | FW |  | Real Valladolid | Valladolid |
| 08/2021 | | Jorge Moreno | DF | | Rayo Vallecano B | Rayo B |
| 08/2021 |  | Kévin Rodrigues | DF |  | Real Sociedad | Real Sociedad |
| 08/2021 | | Martín Merquelanz | MF | | Real Sociedad | Real Sociedad |
| 07/2021 | | Pathé Ciss | MF |  | CF Fuenlabrada | Fuenlabrada |
| 07/2021 |  | Randy Nteka | MF | | CF Fuenlabrada | Fuenlabrada |
| 07/2021 | | Iván Balliu | DF | |||
| 07/2021 | | Sergio Moreno | FW |  | CD Mirandés | Mirandés |
Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 01/2022 |  | Yacine Qasmi | FW |  | CD Leganés | Leganés |
| 01/2022 | | Iván Arboleda | GK |  | Newell's Old Boys | Newell's OB |
| 01/2022 | | Andrés Martín | FW |  | CD Tenerife | Tenerife |
| 01/2022 | | Sergio Moreno | FW |  | SD Amorebieta | SD Amorebieta |
| 01/2022 | | José Pozo | FW |  | Al Ahli Doha | Al Ahli Doha |
| 09/2021 |  | Emiliano Velázquez | DF |  | Santos FC | Santos FC |
| 08/2021 | | Jorge Moreno | DF |  | Cultural Leonesa | CD Leonesa |
| 08/2021 | | Morro | GK | | CF Fuenlabrada | Fuenlabrada |
| 07/2021 |  | Luis Advíncula | MF |  | Boca Juniors | Boca Juniors |
| 07/2021 | | Joni Montiel | MF |  | Real Oviedo | Oviedo |
| 07/2021 | | Martín Pascual | DF |  | Villarreal CF B | Villarreal B |
| 07/2021 | | Iván Martos | DF | | UD Almería | Almería |
| 07/2021 | | Antoñín | FW |  | Granada CF | Granada CF |
| 07/2021 | | Marc | FW | | CD Leganés | Leganés |