Departures
| from | Name | Pos | Team | Team | ||
|---|---|---|---|---|---|---|
| 08/2021 |  | Andrés Lima | DF |  | Cerro Largo | Cerro Largo |
| 07/2021 |  | Héctor Ramírez | GK |  | Jocoro FC | Jocoro FC |
| 07/2021 | | Gustavo Vega | GK |  | Municipal Limeño | Municipal Limeño |
| 07/2021 | | Kevin Calderón | DF | | Jocoro FC | Jocoro FC |
| 07/2021 | | Edson Meléndez | DF |  | FAS | FAS |
| 07/2021 | | Enner Orellana | DF |  | Once Municipal | Once Municipal |
| 07/2021 | | Alexis Renderos | DF |  | Alianza | Alianza |
| 07/2021 | | Kévin Ayala | MF | | FAS | FAS |
| 07/2021 | | René Gómez | MF | | Municipal Limeño | Municipal Limeño |
| 07/2021 | | Carlos Herrera | MF |  | Santa Tecla FC | Santa Tecla FC |
| 07/2021 | | William Maldonado | MF | | Once Municipal | Once Municipal |
| 07/2021 | | Jacobo Moreno | MF | | Santa Tecla FC | Santa Tecla FC |
| 07/2021 | | Marcos Rodríguez | MF |  | AD Chalatenango | Chalatenango |
| 07/2021 | | Levin Espinal | FW | | Jocoro FC | Jocoro FC |
| 07/2021 | | Ricardo Guevara | FW | | AD Chalatenango | Chalatenango |