Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 29.01.2022 |  | Matchday 16 | AE Lárissa - PAOK II | AE - | 0:0 | |
| 02.02.2022 | | Matchday 12 | AE Lárissa - AO Kavala | AE - AO | 3:0 | |
| 19.02.2022 | | Matchday 20 | AE Lárissa - Olympiakos II | AE - | 2:1 | |
| 06.03.2022 | | Matchday 22 | AE Lárissa - Iraklis | AE - Ira | 3:0 | |
| 13.03.2022 | | Matchday 24 | AE Lárissa - Ap. Kalamarias | AE - AKA | 0:0 | |
| 27.03.2022 | | Matchday 26 | AE Lárissa - Pierikos Katerini | AE - | 1:0 | |
| 03.04.2022 | | Matchday 28 | AE Lárissa - Thesprotos | AE - | 1:0 | |
| 10.04.2022 | | Matchday 30 | AE Lárissa - Almopos Arideas | AE - | 2:1 | |
| 17.04.2022 | | Matchday 32 | AE Lárissa - Olymp. Volou | AE - OVO | 0:0 | |
| 19.10.2022 |  | 5. Round | AE Lárissa - Levadiakos | AE - Lev | 1:2 | |
| 06.11.2022 | | Matchday 1 | AE Lárissa - Iraklis Larissa | AE - | 3:0 | |
| 19.11.2022 | | Matchday 3 | AE Lárissa - Niki Volou | AE - PAE | 1:0 | |
| 21.11.2022 | | Matchday 3 | Anagennisi Karditsa - Iraklis Larissa | - | 2:0 | |
| 04.12.2022 | | Matchday 5 | AE Lárissa - Thesprotos | AE - | 2:0 | |
| 18.12.2022 | | Matchday 7 | AE Lárissa - Iraklis | AE - Ira | 0:2 |