Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 13.02.2022 |  | Matchday 17 | Esch - Differdange | CFE - DIF | 2:4 | 357 |
| 06.03.2022 | | Matchday 20 | Esch - UNA Strassen | CFE - | 0:0 | 277 |
| 19.03.2022 | | Matchday 22 | Esch - FC Rodange 91 | CFE - | 8:0 | 143 |
| 10.04.2022 | | Matchday 24 | Esch - FC Wiltz 71 | CFE - FC | 2:1 | 210 |
| 12.04.2022 |  | Group D | Luxembourg - North Macedonia | LUX - MKD | 2:1 | |
| 24.04.2022 | | Matchday 26 | Esch - Jeunesse Esch | CFE - Jeu | 1:0 | 883 |
| 07.05.2022 | | Matchday 28 | Esch - Racing FC | CFE - Rac | 2:0 | 365 |
| 22.05.2022 | | Matchday 30 | Esch - US Mondorf | CFE - | 1:1 | 265 |
| 02.06.2022 |  | Group 6 | Luxembourg - Sweden | LUX - SWE | 0:3 | |
| 07.07.2022 |  | 1. Round First leg | Esch - SP Tre Fiori | CFE - FIO | 0:1 | 925 |
| 07.08.2022 | | Matchday 1 | Esch - UNA Strassen | CFE - | 2:1 | 253 |
| 20.08.2022 | | Matchday 3 | Esch - Etzella | CFE - Etz | 0:0 | 233 |
| 02.09.2022 | | Group D | Luxembourg - N. Ireland | LUX - NIR | 1:2 | |
| 11.09.2022 | | Matchday 6 | Esch - US Mondorf | CFE - | 0:1 | 165 |
| 09.10.2022 | | Matchday 8 | Esch - F91 Dudelange | CFE - F91 | 0:2 | 483 |
| 23.10.2022 | | Matchday 10 | Esch - Vict. Rosport | CFE - Vic | 4:1 | 187 |
| 13.11.2022 | | Matchday 12 | Esch - Jeunesse Esch | CFE - Jeu | 1:3 | 987 |
| 04.12.2022 | | Matchday 14 | Esch - US Hostert | CFE - | 0:1 | 151 |