Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 05.09.2021 |  | Matchday 1 | Sestao River - CD Laredo | Ses - CDL | 2:0 | |
| 19.09.2021 | | Matchday 3 | Sestao River - AD San Juan | Ses - | 2:1 | |
| 03.10.2021 | | Matchday 5 | Sestao River - Burgos Promesas | Ses - | 1:1 | |
| 17.10.2021 | | Matchday 7 | Sestao River - CF Ardoi | Ses - | 4:0 | |
| 31.10.2021 | | Matchday 9 | Sestao River - CD Cayón | Ses - | 3:0 | |
| 20.11.2021 | | Matchday 12 | Sestao River - Osasuna B | Ses - | 1:2 | |
| 05.12.2021 | | Matchday 14 | Sestao River - UD Logroñés Promesas | Ses - | 2:1 |