Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 12.09.2021 |  | Matchday 2 | San Roque - CD Coria | ROQ - | 1:2 | |
| 26.09.2021 | | Matchday 4 | San Roque - UD Tamaraceite | ROQ - | 1:0 | |
| 10.10.2021 | | Matchday 6 | San Roque - CD Mensajero | ROQ - CDM | 4:1 | |
| 23.10.2021 | | Matchday 8 | San Roque - UD Montijo | ROQ - | 1:2 | |
| 30.10.2021 | | Matchday 9 | San Roque - Córdoba | ROQ - COR | 0:1 | |
| 13.11.2021 | | Matchday 11 | San Roque - Villanovense | ROQ - Vil | 2:0 | |
| 28.11.2021 | | Matchday 13 | San Roque - UD Las Palmas B | ROQ - | 1:1 | |
| 01.12.2021 |  | 1. Round | San Roque - Mirandés | ROQ - MIR | 0:3 | |
| 12.12.2021 | | Matchday 15 | San Roque - AD Ceuta FC | ROQ - | 2:2 |