Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 15.05.2022 |  | Matchday 12 | Cerro Largo - Maldonado | CLF - Dep | 1:0 | |
| 28.05.2022 | | Matchday 14 | Cerro Largo - Liverpool FC | CLF - LFC | 1:2 | |
| 20.06.2022 | | Group B | Cerro Largo - Plaza Colonia | CLF - CAP | 1:0 | |
| 17.07.2022 | | Group B | Cerro Largo - Nacional | CLF - Nac | 0:0 | |
| 25.07.2022 | | Group B | Cerro Largo - River Plate | CLF - Riv | 0:0 | |
| 31.07.2022 | | Matchday 1 | Cerro Largo - Torque | CLF - MCT | 1:2 | |
| 06.08.2022 | | Matchday 2 | Cerro Largo - Wanderers | CLF - MWF | 1:1 | |
| 29.08.2022 | | Matchday 5 | Cerro Largo - River Plate | CLF - Riv | 0:5 | |
| 04.09.2022 | | Matchday 4 | Cerro Largo - Boston River | CLF - Bos | 1:1 | |
| 11.09.2022 | | Matchday 7 | Cerro Largo - Fénix | CLF - Fén | 1:0 | |
| 18.09.2022 | | Matchday 9 | Cerro Largo - Albion | CLF - AFC | 1:2 | |
| 30.09.2022 | | Matchday 11 | Cerro Largo - Danubio | CLF - Dan | 1:0 | |
| 11.10.2022 | | Matchday 13 | Cerro Largo - Rentistas | CLF - C.A | 2:1 |