Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 16.04.2022 |  | Matchday 1 | Mushuc Runa - Cumbayá | - | 1:1 | |
| 16.04.2022 |  | Matchday 1 | Mushuc Runa - Cumbayá | - | 0:0 | |
| 30.04.2022 | | Matchday 3 | Mushuc Runa - El Nacional | - | 3:4 | |
| 30.04.2022 | | Matchday 3 | Mushuc Runa - El Nacional | - | 2:2 | |
| 21.05.2022 | | Matchday 6 | Mushuc Runa - América de Quito | - | 3:1 | |
| 21.05.2022 | | Matchday 6 | Mushuc Runa - América de Quito | - | 1:1 | |
| 10.06.2022 | | Matchday 9 | Mushuc Runa - Macará | - | 4:3 | |
| 10.06.2022 | | Matchday 9 | Mushuc Runa - Macará | - | 0:1 | |
| 23.07.2022 | | Matchday 12 | Mushuc Runa - Tecnico Universitario | - | 7:0 | |
| 23.07.2022 | | Matchday 12 | Mushuc Runa - Técnico Universitario | - | 5:1 | |
| 06.08.2022 | | Matchday 14 | Mushuc Runa - Chacaritas FC | - | 6:1 | |
| 06.08.2022 | | Matchday 14 | Mushuc Runa - Chacaritas FC | - | 4:1 | |
| 27.08.2022 | | Round of 16 2nd leg | Mushuc Runa - Aucas | - | 4:2 | |
| 03.09.2022 | | Quarter-finals First leg | Mushuc Runa - Independiente del Valle | - | 2:3 |