Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 22.01.2022 |  | Matchday 2 | Leones Negros II - Mazorqueros | - MFC | 0:1 | 50 |
| 05.02.2022 | | Matchday 4 | Leones Negros II - Colima | - CFC | 1:2 | 50 |
| 12.02.2022 | | Matchday 5 | Leones Negros II - Correcaminos UAT II | - | 0:1 | 50 |
| 26.02.2022 | | Matchday 7 | Leones Negros II - Mineros | - MdF | 0:0 | 50 |
| 12.03.2022 | | Matchday 9 | Leones Negros II - Alacranes | - Ala | 2:4 | 50 |
| 26.03.2022 | | Matchday 11 | Leones Negros II - Saltillo | - SFC | 2:1 | 50 |
| 10.04.2022 | | Matchday 13 | Leones Negros II - Catedráticos | - | 0:0 | 100 |
| 27.08.2022 | | Matchday 1 | Leones Negros II - Mineros | - MdF | 3:1 | 50 |
| 07.09.2022 | | Matchday 3 | Leones Negros II - Cimarrones de Sonora II | - | 2:3 | 100 |
| 10.09.2022 | | Matchday 4 | Halcones - Tecos | HAL - TFC | 3:1 | 100 |
| 24.09.2022 | | Matchday 6 | Leones Negros II - Dragones | - DRA | 5:0 | 50 |
| 01.10.2022 | | Matchday 8 | Leones Negros II - Tritones | - TVa | 0:3 | 100 |
| 27.10.2022 | | Semi-finals First leg | Leones Negros II - Cimarrones de Sonora II | - | 0:3 | 100 |