Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 17.09.2021 |  | Matchday 2 | Ionikos - Aris Saloniki | Ion - Ari | 1:0 | 769 |
| 23.09.2021 | | Matchday 3 | Ionikos - PAS Giannina | Ion - Gia | 0:0 | 999 |
| 03.10.2021 | | Matchday 5 | Ionikos - Lamia | Ion - LAM | 1:2 | 856 |
| 01.11.2021 | | Matchday 8 | Ionikos - Volos NFC | Ion - VOL | 1:1 | 932 |
| 20.11.2021 | | Matchday 10 | Ionikos - Asteras | Ion - TRI | 1:1 | 741 |
| 05.12.2021 | | Matchday 12 | Ionikos - PAOK | Ion - PAO | 3:2 | 1.265 |
| 16.12.2021 | | Matchday 14 | Ionikos - AEK Athen | Ion - AEK | 0:1 | 1.375 |