Gameplan
| Date | Round | Match | Match | Res. | Attendance | |
|---|---|---|---|---|---|---|
| 07.01.2022 |  | Matchday 1 | Pumas - CF Monterrey II | SPT - | 0:1 | 685 |
| 20.01.2022 | | Matchday 3 | Pumas - Tampico Madero | SPT - | 2:0 | 575 |
| 02.02.2022 | | Matchday 6 | Pumas - Celaya | SPT - Cel | 0:1 | 1.008 |
| 17.02.2022 | | Matchday 8 | Pumas - Tapatío | SPT - TAP | 2:1 | 1.319 |
| 03.03.2022 | | Matchday 10 | Pumas - Zacatecas | SPT - | 0:5 | 364 |
| 10.03.2022 | | Matchday 11 | Pumas - Tlaxcala | SPT - CdT | 0:0 | Unter Ausschluss der Öffentlichkeit. |
| 23.03.2022 | | Matchday 13 | Pumas - Cimarrones | SPT - | 2:2 | 375 |
| 31.03.2022 | | Matchday 15 | Pumas - Correcaminos | SPT - Cor | 1:2 | 585 |
| 14.04.2022 | | Matchday 17 | Pumas - Morelia | SPT - Mor | 0:1 | 431 |
| 27.06.2022 | | Matchday 1 | Pumas - Cancún | SPT - CFC | 1:2 | 1.570 |
| 15.07.2022 | | Matchday 3 | Pumas - Oaxaca | SPT - AdO | 0:2 | 1.100 |
| 28.07.2022 | | Matchday 5 | Pumas - Zacatecas | SPT - | 1:1 | 1.400 |
| 19.08.2022 | | Matchday 8 | Pumas - Atlante | SPT - AFC | 1:1 | 2.010 |
| 01.09.2022 | | Matchday 10 | Pumas - Tapatío | SPT - TAP | 1:0 | 1.045 |
| 14.09.2022 | | Matchday 12 | Pumas - UdeG | SPT - Ude | 0:2 | 1 |
| 25.09.2022 | | Matchday 14 | Pumas - Cimarrones | SPT - | 0:1 | 450 |
| 05.10.2022 | | Matchday 16 | Pumas - Dorados | SPT - Dor | 0:3 | 360 |